Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

F - Nucleotide transport and metabolism

Download

Stats

COG
definitions
Organims Proteins Median Protein
Length
Genes
129 1,308 102,508 302.0 120
Organism Protein COG Cat Annotation
924 1145 COG0005 F Purine nucleoside phosphorylase
1221 1496 COG0015 F Adenylosuccinate lyase
907 923 COG0026 F Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)
323 329 COG0027 F Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)
1181 1258 COG0034 F Glutamine phosphoribosylpyrophosphate amidotransferase
937 974 COG0035 F Uracil phosphoribosyltransferase
1188 1207 COG0041 F Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
1106 1924 COG0044 F Dihydroorotase or related cyclic amidohydrolase
1170 1184 COG0046 F Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain
1171 1174 COG0047 F Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
1042 1056 COG0062 F NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain
1137 1194 COG0063 F NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain
749 1136 COG0075 E F Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG
1215 1285 COG0104 F Adenylosuccinate synthase
1162 1185 COG0105 F Nucleoside diphosphate kinase
1183 1427 COG0125 F Thymidylate kinase
1243 1293 COG0127 F Inosine/xanthosine triphosphate pyrophosphatase, all-alpha NTP-PPase family
1145 1221 COG0138 F AICAR transformylase/IMP cyclohydrolase PurH
1176 1183 COG0150 F Phosphoribosylaminoimidazole (AIR) synthetase
1177 1231 COG0151 F Phosphoribosylamine-glycine ligase
1188 1249 COG0152 F Phosphoribosylaminoimidazole-succinocarboxamide synthase
1222 1627 COG0167 F Dihydroorotate dehydrogenase
1144 1200 COG0194 F Guanylate kinase
862 900 COG0207 F Thymidylate synthase
834 983 COG0208 F Ribonucleotide reductase beta subunit, ferritin-like domain
1179 1641 COG0209 F Ribonucleotide reductase alpha subunit
644 685 COG0213 F Thymidine phosphorylase
845 961 COG0232 F dGTP triphosphohydrolase
973 1464 COG0248 T F Exopolyphosphatase/pppGpp-phosphohydrolase
799 947 COG0274 F Deoxyribose-phosphate aldolase
1122 1128 COG0283 F Cytidylate kinase
1216 1259 COG0284 F Orotidine-5'-phosphate decarboxylase
788 856 COG0295 F Cytidine deaminase
1098 1128 COG0299 F Folate-dependent phosphoribosylglycinamide formyltransferase PurN
433 581 COG0369 F P Flavoprotein (flavin reductase) subunit CysJ of sulfite and N-hydroxylaminopurine reductases
934 2518 COG0402 F R Cytosine/adenosine deaminase or related metal-dependent hydrolase
358 360 COG0418 F Dihydroorotase
1184 1545 COG0458 E F Carbamoylphosphate synthase large subunit
1221 1302 COG0461 F Orotate phosphoribosyltransferase
1274 1554 COG0462 F Phosphoribosylpyrophosphate synthetase
1037 1565 COG0503 F Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein
1239 1292 COG0504 F CTP synthase (UTP-ammonia lyase)
1164 1216 COG0505 E F Carbamoylphosphate synthase small subunit
1190 1634 COG0516 F IMP dehydrogenase/GMP reductase
1236 2128 COG0518 F GMP synthase, glutamine amidotransferase domain
1229 1256 COG0519 F GMP synthase, PP-ATPase domain/subunit
1272 1317 COG0528 F Uridylate kinase
1278 2350 COG0537 F R Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family
1185 1218 COG0540 F Aspartate carbamoyltransferase, catalytic subunit
1239 1704 COG0563 F Adenylate kinase or related kinase
649 885 COG0572 F Uridine kinase
833 1304 COG0613 F 5'-3' exoribonuclease TrpH/YciV (RNase AM), contains PHP domain
682 1013 COG0618 T F nanoRNase/pAp phosphatase, hydrolyzes c-di-AMP and oligoRNAs
918 983 COG0634 F Hypoxanthine-guanine phosphoribosyltransferase
622 911 COG0647 F Ribonucleotide monophosphatase NagD, HAD superfamily
872 986 COG0717 F dCTP deaminase
782 1524 COG0737 V F 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family
951 986 COG0756 V F dUTP pyrophosphatase (dUTPase)
757 1090 COG0775 F H Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB
650 775 COG0788 F Formyltetrahydrofolate hydrolase
348 372 COG0813 F Purine-nucleoside phosphorylase
66 69 COG0856 F Orotate phosphoribosyltransferase homolog
388 490 COG1001 F Adenine/N6-methyladenosine deaminase
1195 5150 COG1051 F ADP-ribose pyrophosphatase YjhB, NUDIX family
549 928 COG1079 F ABC-type guanosine uptake system NupNOPQ, permease subunit NupQ
267 365 COG1102 F Cytidylate kinase
637 1004 COG1146 F NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit
657 665 COG1286 M F Colicin V production accessory protein CvpA, regulator of purF expression and biofilm formation
603 741 COG1328 F Anaerobic ribonucleoside-triphosphate reductase
452 465 COG1351 F Thymidylate synthase ThyX, FAD-dependent family
298 445 COG1428 F Deoxyadenosine/deoxycytidine kinase
626 638 COG1435 F Thymidine kinase
437 731 COG1457 F Purine-cytosine permease or related protein
1033 1624 COG1611 F Nucleotide monophosphate nucleosidase PpnN/YdgH, Lonely Guy (LOG) family
120 125 COG1618 F Nucleoside-triphosphatase THEP1
316 329 COG1691 F NCAIR mutase (PurE)-related protein
65 122 COG1759 F 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase (purine biosynthesis)
199 220 COG1780 F Flavodoxin NrdI, NrdF-interacting activator of class Ib ribonucleotide reductase
280 280 COG1781 F Aspartate carbamoyltransferase, regulatory subunit
531 781 COG1816 F Adenosine/6-amino-6-deoxyfutalosine deaminase
636 634 COG1828 F Phosphoribosylformylglycinamidine (FGAM) synthase, PurS subunit
116 116 COG1839 F Adenosine/AMP kinase
84 84 COG1860 L F Predicted metal-binding protein, contains two cysteine clusters, UPF0179 family
249 330 COG1864 F DNA/RNA endonuclease G, NUC1
525 667 COG1896 F R 5'-deoxynucleotidase YfbR and related HD superfamily hydrolases
147 152 COG1936 F Broad-specificity NMP kinase
205 270 COG1953 F H Cytosine/uracil/thiamine/allantoin permease
501 877 COG1957 F Inosine-uridine nucleoside N-ribohydrolase
358 497 COG1972 F Nucleoside permease NupC
197 202 COG1986 V F Non-canonical (house-cleaning) NTP pyrophosphatase, all-alpha NTP-PPase family
83 91 COG2019 F Archaeal adenylate kinase
635 722 COG2065 F Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase
504 522 COG2131 F Deoxycytidylate deaminase
664 1168 COG2233 F Xanthine/uracil permease
702 968 COG2252 F Xanthine/guanine/uracil/vitamin C permease GhxP/GhxQ, nucleobase:cation symporter 2 ( NCS2) family
580 745 COG2258 V F N-hydroxylaminopurine reductase YiiM, contains MOSC domain
242 250 COG2313 F Pseudouridine-5'-phosphate glycosidase (pseudoU degradation)
339 386 COG2351 F 5-hydroxyisourate hydrolase (purine catabolism), transthyretin-related family
306 408 COG2357 T F ppGpp synthetase catalytic domain (RelA/SpoT-type nucleotidyltranferase)
69 73 COG2429 F Archaeal GTP cyclohydrolase III
489 512 COG2759 F Formyltetrahydrofolate synthetase
559 636 COG2816 F NADH pyrophosphatase NudC, Nudix superfamily
381 519 COG2820 F Uridine phosphorylase
242 243 COG3123 F Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family
179 211 COG3194 F Ureidoglycolate hydrolase (allantoin degradation)
307 344 COG3195 F 2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) decarboxylase (uric acid degradation)
176 197 COG3199 F NAD kinase
423 475 COG3217 V F N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain
168 187 COG3257 F Ureidoglycine aminohydrolase
77 77 COG3363 F Archaeal IMP cyclohydrolase
169 193 COG3613 F Nucleoside 2-deoxyribosyltransferase
542 915 COG3845 F ABC-type guanosine uptake system NupNOPQ, ATPase component NupO
12 13 COG4027 F 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase
102 107 COG4119 F R Predicted NTP pyrophosphohydrolase, NUDIX family
89 99 COG4266 F Allantoicase
165 179 COG4290 F Guanyl-specific ribonuclease Sa
104 126 COG4317 F Xanthosine utilization system component, XapX domain
66 67 COG4360 F ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II)
100 103 COG4502 F 5'(3')-deoxyribonucleotidase
64 74 COG4508 F Dimeric dUTPase, all-alpha-NTP-PPase (MazG) superfamily
547 921 COG4603 F ABC-type guanosine uptake system NupNOPQ, permease component NupP
235 252 COG4630 F Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA
232 246 COG4631 F Xanthine dehydrogenase, molybdopterin-binding subunit XdhB
98 98 COG4696 F NTP pyrophosphatase, MazG superfamily
125 135 COG4708 J F ECF-type transporter of queuosine precursor, membrane (S) component
27 27 COG4741 F Predicted secreted endonuclease distantly related to archaeal Holliday junction resolvase
27 35 COG4855 F Uncharacterized conserved protein
57 76 COG5042 F Purine nucleoside permease
4 5 COG5371 F Nucleoside diphosphatase, GDA1/CD39 family