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| Status |
Public on May 01, 2024 |
| Title |
Multi-omics analysis reveals altered lipid metabolism in the skin of high fat diet-fed mice of atopic dermatitis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To identify the obesity-induced exacerbating mechanisms of AD symptoms by multi-omics analysis. Then, we demonstrated the therapeutic effect of GHJGS in circulating lipid profiles.
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| Overall design |
For diet-induced obesity, mice were fed a HF diet (60 kcal% fat, D12492, Research Diets, New Brunswick, NJ) for up to 4 weeks before the induction of AD. Sham groups were fed a normal autoclave rodent chow (38057, Purina Korea, Seoul, Korea). After the induction of obesity for 4 weeks, (1) the sham [normal diet + vehicle + distilled water (DW)]; (2) AD [normal diet + 2,4-dinitrochlorobenzene (DNCB) + DW]; (3) HF+AD (HF diet + DNCB + DW) (4) HF+AD+GHJGS; HF diet + DNCB+ GHJGS 617 mg/kg/day) for 6 weeks. To induce AD, dorsal skin was applied three times a week with 0.5% DNCB mixed in acetone/olive oil (3:1).
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| Contributor(s) |
Jung J, Ahn YM |
| Citation(s) |
38673730 |
| Submission date |
Mar 09, 2023 |
| Last update date |
May 02, 2024 |
| Contact name |
Jeeyoun jung |
| E-mail(s) |
zzen0918@gmail.com
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| Organization name |
Korea institute of Oriental Medicine
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| Street address |
Yuseong daero 1672
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| City |
DAEJEON |
| ZIP/Postal code |
34054 |
| Country |
South Korea |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA942948 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE227042_RAW.tar |
1.4 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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