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| Status |
Public on May 07, 2024 |
| Title |
DAPK1 acts as a positive regulator of hypertension via induction of vasoconstriction |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The objective of this research is to compare the differentially expressed genes in the vascular tissues of DAPK1 wild-type (WT) and DAPK1 knockout (KO) mice after being induced with or without Ang II. WT (n=10) mice were randomly divided into two groups: WT+NS group and WT+Ang II group (n=5 for each group). KO (n=10) mice were also randomly divided into two groups: KO+NS group and KO+Ang II group (n=5 for each group). Then the vascular tissues were used to identify differentially expressed genes among different groups.
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| Overall design |
RNA sequencing was performed with vascular tissues of mice in 4 groups: WT+NS , WT+Ang II, KO+NS ，KO+Ang II to identify the differently expressed genes and related pathway.
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| Contributor(s) |
Peng J, Shen A, Lin Y, Zhang X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 04, 2024 |
| Last update date |
May 07, 2024 |
| Contact name |
Jun Peng |
| E-mail(s) |
pjunlab@hotmail.com
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| Organization name |
Fujian University of Traditional Chinese Medicine
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| Department |
Academy of Integrative Medicine
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| Street address |
1 Qiuyang Road, Minhou Shangjie
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| City |
Fuzhou |
| State/province |
Fujian |
| ZIP/Postal code |
350122 |
| Country |
China |
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| Platforms (1) |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA1096309 |
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