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| Status |
Public on May 01, 2024 |
| Title |
RORĪ³t -expressing FOXP3+ skin-resident Treg cells derived from the periphery in Allergen-Specific Immunotherapy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The study explored the impact of Specific Immunotherapy on patients with Atopic Dermatitis sensitized to house dust mites by analyzing the transcriptomes of T regulatory cells before and after treatment. Result found that effective SIT is associated with distinct gene expression changes in Treg cells, particularly increased expression of Treg markers and RORC, a gene linked to immune regulation. These results indicate that successful SIT may enhance the function of Treg cells expressed RORC and help restore immune balance in these patients.
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| Overall design |
Patients with Atopic Dermatitis (AD) sensitized to house dust mites are divided into two groups based on their response to Specific Immunotherapy (SIT): those who showed an effective response (R) and those who did not respond (Non-R). Results identified differentially expressed genes before and after SIT in R and Non-R groups.
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| Contributor(s) |
Park CO |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 28, 2023 |
| Last update date |
May 01, 2024 |
| Contact name |
Kelun Zhang |
| E-mail(s) |
zhangkelun@hotmail.com
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| Phone |
01088069381
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| Organization name |
Yonsei university
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| Department |
Dermatology
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| Lab |
Skin immunology Lab
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| Street address |
50-1, Yonsei-Ro, Seodaemun-gu
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| City |
Seoul |
| State/province |
Seoul |
| ZIP/Postal code |
03722 |
| Country |
South Korea |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA1058556 |
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