(smok* OR diet) AND (mammals[organism] NOT human[organism]) - GEO DataSets

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Select item 2002665651.

Elucidating the Onset of Cross-protective Immunity after Intranasal Vaccination with the Attenuated African Swine Fever Vaccine Candidate BA71ΔCD2

(Submitter supplied) African swine fever (ASF) is a deadly disease of swine currently causing a worldwide pandemic leading to severe economic consequences for the porcine industry. The control of disease spread is hampered by the limitation of available effective vaccines. Live attenuated vaccines (LAVs) are currently the most advanced vaccine prototypes, providing strong protection against ASF. However, the significant advances achieved using LAVs must be complemented with further studies to analyse vaccine-induced immunity. more...

Organism:: Sus scrofa domesticus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29562
60 Samples

Download data: TXT

Series

Accession:: GSE266565

ID:: 200266565

Select item 2002664012.

Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (BPA)

(Submitter supplied) Pregannt Cyp19-EGFP mice (maintained on a soybean free mouse chow diet) were treated with either 50μg/kg/day Bsiphenol A or vehicle (ethinol in peanut oil) between gestational days (GD) 10.5-14.5. On GD15.5, fetuses were dissected and sex determined by SRY genotyping. Fetuses were obtained from different dams.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16417
6 Samples

Download data: CSV

Series

Accession:: GSE266401

ID:: 200266401

Select item 2002660403.

Therapeutic targeting of PKM2 ameliorates NASH fibrosis progression in a macrophage-specific and liver-specific manner

(Submitter supplied) Nonalcoholic steatohepatitis (NASH) might soon become the leading cause of end-stage liver disease worldwide with limited treatment options. Liver fibrosis, driven by chronic inflammation and hepatic stellate cells (HSCs) activation, critically determines morbidity and mortality in patients with NASH. Pyruvate kinase M2 (PKM2) is involved in immune activation and inflammatory liver diseases; however, its role and therapeutic potential in NASH fibrosis remain largely unexplored. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE266040

ID:: 200266040

Select item 2002664774.

Semaglutide interferes with postnatal growth in a diet-dependent manner

(Submitter supplied) Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been shown to impact glucose homeostasis and, more recently, the somatotropic axis. While the effects of GLP-1RAs have been extensively studied in the context of diet-induced obesity, their impact on physiology in other nutritional contexts have been less explored. We investigated the potential beneficial effects of the GLP-1RA semaglutide during juvenile protein malnutrition, a dietary challenge known to cause stunted growth and to disrupt metabolic homeostasis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
10 Samples

Download data: TSV

Series

Accession:: GSE266477

ID:: 200266477

Select item 2002305665.

Chronic inflammatory activation of arterial endothelial cells in mice under normal lipoprotein/cholesterol levels and on normal diet.

(Submitter supplied) Inflammatory activation of endothelial cells is considered to be the first step in the development of atherosclerosis. Here, we determined changes of aortic gene expression after chronic inflammatory activation of arterial endothelial cells in genetically modified mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
8 Samples

Download data: TSV, TXT

Series

Accession:: GSE230566

ID:: 200230566

Select item 2002662966.

The role of macrophage VCAM-1 in atherosclerosis and inflammation

(Submitter supplied) VCAM-1 is known to be expressed by endothelial cells. We showed that this is also expressed by atherosclerotic plaque macrophages. However, the merit of this adhesion molecule is now known in atherosclerosis. In this RNA sequencing experiment, we analyzed VCAM-1+ vs. - atherosclerotic plaque macrophages. Additionally, we sorted macrophages from atherosclerotic plaques of mice after mitochondrial biogenesis gene Cmpk2 silencing in macrophages in vivo.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
28 Samples

Download data: RDS, XLSX

Series

Accession:: GSE266296

ID:: 200266296

Select item 2002642537.

IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering

(Submitter supplied) Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions are the leading cause of death in the world. The most common and effective means to reduce these major adverse cardiovascular events (MACE), including myocardial infarction (MI) and stroke, is aggressive lipid lowering via a combination of drugs and dietary modifications. However, little is known regarding the effects of reducing dietary lipids on the composition and stability of advanced atherosclerotic lesions, the mechanisms that regulate these processes, and what therapeutic approaches might augment the benefits of lipid lowering.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16417
8 Samples

Download data: TAR

Series

Accession:: GSE264253

ID:: 200264253

PubMed Similar studies

Select item 2002201418.

Transcriptome analysis of repopulated microglia after 7 days of PLX5622 treatment and 10 days of PLX5622 withdrawal

(Submitter supplied) Microglia are suspected to be a key player in several neurological diseases. Here, we investigated whether microglia depletion affects dendritic spine density after short-term microglia depletion with subsequent repopulation in the adult mouse brain.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: CSV

Series

Accession:: GSE220141

ID:: 200220141

Select item 2002412729.

YTHDC1 is essential for cardiac development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data

Series

Accession:: GSE241272

ID:: 200241272

Select item 20024127010.

YTHDC1 is essential for cardiac development [ATAC-seq]

(Submitter supplied) The goal of this study is to investigate how YTHDC1 regulate cardiac development.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: TXT

Series

Accession:: GSE241270

ID:: 200241270

Select item 20023199111.

Diet-induced obesity dysregulates rapid epigenetic response to hypoxia in macrophages (ChIP-Seq)

(Submitter supplied) Macrophages play important roles in tissue homeostasis and tissue healing process. The response to hypoxic environment is a trigger to induce key signaling pathways in macrophages. Functions of macrophages are dysregulated in metabolic diseases such as diabetes and obesity resulting in poor tissue healing. Epigenetic status including histone modification in macrophages is regulated by hypoxia. However, whether and how obesity influences histone modification under hypoxia is unknown. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE231991

ID:: 200231991

Select item 20023939112.

Single-cell RNA sequencing Reveals Obesity-Induced Inhibition of Testosterone Production and Damage of Blood-Testis Barrier Integrity

(Submitter supplied) Obesity is accompanied by multiple known health risks and increased morbidity, and the prevalence of obesity continues to rise. Fertility in males of reproductive age is affected by the endocrine abnormalities and comorbidities associated with obesity, which has become a primary cause of male infertility. Single-cell RNA sequencing (scRNA-seq) of testes in obese individuals has not been done, so we chose to use this technique to study the mechanism of infertility in an obese mouse model.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: MTX, TAR, TSV

Series

Accession:: GSE239391

ID:: 200239391

Select item 20026607713.

Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for the histone modifications H3K27ac and H3K9me3 in liver tissues from MCD and regular chow diet mice

(Submitter supplied) Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for the histone modifications H3K27ac and H3K9me3 in liver tissues from Methionine- and choline-deficient diet (MCD) and regular chow diet mice.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21273
18 Samples

Download data: BW

Series

Accession:: GSE266077

ID:: 200266077

Select item 20026397514.

RNA-seq analysis of naïve and MASH liver tissue.

(Submitter supplied) This analysis was perfomed to explore microevironmental cues that may induce Egr2 expression in infiltrating monocytes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: XLSX

Series

Accession:: GSE263975

ID:: 200263975

Select item 20026397315.

EGR2 is upregulated in monocyte-derived macrophages in MASH liver

(Submitter supplied) This analysis was perfomed to explore the transcription factors that were enhanced in MASH liver macrophages.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

Download data: XLSX

Series

Accession:: GSE263973

ID:: 200263973

Select item 20025547416.

Characterisation of the epidermal diurnal transcriptome of mice with K14-Cre-driven Bmal1 knockout

(Submitter supplied) To preserve a state of health, mammals employ an integrated network of molecular oscillators to drive daily rhythms of tissue-specific homeostatic processes. Importantly, the output, structure and coherence of this network is compromised by physiological ageing, disease and lifestyle changes. Yet, the key signalling nodes in this network, their underlying mechanisms of communication, and potential for therapeutic intervention, remain undefined. more...