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Study Description

Method: Enzyme-linked Immunosorbent Assay (EIA) (R&D kit # HSTA00C)

Technical Aspects:

    VendorR & D Systems, Minneapolis, MN
    Unitspg/mL
    Minimum Detectable Level0.06 - 0.32 pg/mL

FHS Specimen Characteristics:

    a. Plasma

    b. Frozen samples -80°C

Authorized Access
Publicly Available Data
Study History

Offspring Exam 7 (2537 participants)

The Original cohort began Exam 1 in 1948 (9/1948 - 4/1953) and has continued with biennial examinations to the present. Exam 29 was performed from 4/2006 - 12/2007.

The Offspring cohort began Exam 1 in 1971 (8/1971 - 9/1975) and has on average been examined every 3 to 4 years since enrollment. However, there was an eight year window between Exam 1 and Exam 2. Exam 8 was performed from 3/2005 - 1/25/2008.

The Generation 3 cohort Exam 1 was performed 4/2002 - 7/2005.

Examination of all three cohorts is ongoing.

Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Authorized Data Access Requests
Study Attribution
  • Principal Investigator
    • James Meigs, MD, MPH. Massachusetts General Hospital, Boston, MA, USA.
  • Institutions
    • The National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.