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Study Description

Cohort Exam 22 and Offspring Exam 6 were studied:

  • To "examine the epidemiology of presbycusis in relation to biomedical risk factors with the goal of determining the relative contributions of age-related degeneration and age-related diseases to a.) presbycusis in general, b) the major sites of dysfunction, i.e. cochlear, retrococlear and central and c) the specific types of presbycusis, i.e. sensory, neural, strial and conductive."
  • The testing would "provide the first 15 year longitudinal analysis of the incidence of hearing loss in elderly men and women."
  • There was a more detailed questionnaire/history form as well as an inventory called the HHIE (Hearing Handicap Inventory for the Elderly).
  • Testing was most often done in 2 parts-the first part included questionnaires, basic hearing assessment and evaluation of middle ear function. Part 2, usually completed on a subsequent date, included central auditory tests.
  • In addition to looking at biomedical risk factors of presbycusis, the goals of Offspring Exam 6 included identifying "families with evidence of genetic transmission of presbycusis" and looking at the relation of hearing levels and cognitive function.
    • Authorized Access
    Publicly Available Data
    Study History

    Cohort Exam 22 and Offspring Exam 6

    The Generation 1 (or Original) cohort Exam 1 took place between 1948 and 1953. Biennial exams have continued to the present. Exam 29 took place between 2006 and 2007. Exam 30 began in 2008.

    The Generation 2 (or Offspring) cohort Exam 1 took place between 1971 and 1975. This cohort on average has been examined every three to four years. However, there was an eight year gap between Exam 1 and Exam 2 and a seven year gap between Exam 7 and Exam 8. Exam 8 took place between 2005 and 2008.

    The Generation 3 cohort Exam 1 took place between 2002 and 2005. Exam 2 began in 2008.

    The New Offspring Spouse cohort Exam 1 took place between 2003 and 2005. Exam 2 began in 2008.

    Selected Publications
    Diseases/Traits Related to Study (MeSH terms)
    Authorized Data Access Requests
    Study Attribution
    • Principal Investigators
      • George Gates, MD. University of Washington, Seattle, WA, USA.
      • Margaret Skinner, PhD. Washington Unversity, St. Louis, MO, USA.
    • Institution
      • The National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.