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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 28, 2007 |
| Title |
Expression profile from anthrax edema toxin (ET) treated murine bone marrow derived macrophages (BMDM) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Bacillus anthracis, the causative agent of anthrax, secretes three toxin proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA is a transporter of LF and EF into host cells by receptor-mediated endocytosis. LF is a metalloprotease that cleaves mitogen-activated protein kinase (MAPK) kinases (MKK), while EF is an adenylate cyclase, which converts ATP to cAMP.
We used microarrays to decipher the specific gene regulation in edema toxin (ET), the complex of EF and PA, treated mouse bone marrow derived macrophages.
Keywords: Time course
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| Overall design |
BMDM were treated with 1 mg/ml of ET and the RNAs were purified at 0, 2, and 4h after toxin treatment.
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| Contributor(s) |
Park JM, Kim C |
| Citation(s) |
18427110 |
| Submission date |
Sep 27, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Chun Kim |
| E-mail(s) |
chun.kim@cbrc2.mgh.harvard.edu
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| Phone |
617-726-4456
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| Fax |
617-726-4453
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| Organization name |
Massachusetts General Hospital
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| Department |
Cutaneous Biology Research Center
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| Street address |
Bldg 149, 13th Street
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| City |
Charlestown |
| State/province |
MA |
| ZIP/Postal code |
02129 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA102751 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE9184_RAW.tar |
12.6 Mb |
(http)(custom) |
TAR (of CEL, CHP, EXP) |
| Processed data included within Sample table |
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