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| Status |
Public on Apr 14, 2008 |
| Title |
Dnmt3l-/+ (maternal methylation-deficient) vs normal 8.5dpc embryos |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
During oogenesis, DNA methyltransferase 3-like (Dnmt3l) is required for the establishment of the maternal germline DNA methylation imprints that in the offspring, govern the parent-of-origin-specific expression of most known imprinted genes (Science 2001, 294:2536-9). Dnmt3l-deficient dams were crossed with wildtype sires to obtain Dnmt3l-/+ embryos that lack maternal methylation imprints. Gene expression was measured in Dnmt3l-/+ and wildtype embryos and is expected to differ for imprinted genes that are under the control of a maternal methylation mark.
Keywords: genetic modification, DNA methylation
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| Overall design |
1 normal control sample/array. 2 biologically replicate Dnmt3l-/+ samples/arrays.
|
| Web link |
https://atlas.genetics.kcl.ac.uk/
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| |
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| Contributor(s) |
Schulz R, Woodfine K, Menheniott T, Bourc'his D, Bestor T, Oakey R |
| Citation(s) |
18398312 |
| Submission date |
Aug 13, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Reiner Schulz |
| E-mail(s) |
reiner.schulz@kcl.ac.uk
|
| Organization name |
King's College London
|
| Department |
Medical & Molecular Genetics
|
| Lab |
Epigenetics
|
| Street address |
8th floor Guy's Tower
|
| City |
London |
| ZIP/Postal code |
SE1 9RT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA102029 |
