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| Status |
Public on Jul 31, 2008 |
| Title |
Microarray analysis identifies distinct subpopulations of arthritic mice deficient for interleukin 1 receptor antagonist |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Rheumatoid arthritis (RA) is a heterogeneous disease with clinical and biological polymorphisms. However, little is known about baseline molecular variations among individual RA patients. The purpose of this study was to address this issue using F2 intercross mice generated from arthritis-prone BALB/c and arthritis-resistant DBA/1 mice deficient for interleukin 1 receptor antagonist (Il1rn). Two distinct subpopulations of arthritic mice were identified in the 38 mice studied. One subgroup of diseased mice was characterized by myeloid cell dominant inflammation, whereas the other was mainly associated with increased anti-apoptotic activities of inflammatory cells.
Keywords: disease state analysis
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| Overall design |
Thirteen F2 mice, 18 with arthritis and 18 without, were included in this study. Total RNAs were extracted from individual spleens for Affymmetrix mouse genome array analysis. Normalized data were hierarchically clustered to identify subpopulations of arthritic mice.
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| Contributor(s) |
Yan J, Jiao Y, Stuart J, Gu W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 03, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Jian Yan |
| E-mail(s) |
jyan1@utmem.edu
|
| Phone |
901-448-7830
|
| Organization name |
University of Tennessee Health Science Center
|
| Department |
Orthopedics Surgery
|
| Lab |
Weikuan Gu
|
| Street address |
956 Court Ave
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38163 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (36)
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| Relations |
| BioProject |
PRJNA101909 |
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