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| Status |
Public on Jun 11, 2016 |
| Title |
caArray_meyer-00191: Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We have generated a molecular taxonomy of lung carcinoma, the leading cause of cancer death in the United States and worldwide. Using oligonucleotide microarrays, we analyzed mRNA expression levels corresponding to 12,600 transcript sequences in 186 lung tumor samples, including 139 adenocarcinomas resected from the lung. Hierarchical and probabilistic clustering of expression data defined distinct subclasses of lung adenocarcinoma. Among these were tumors with high relative expression of neuroendocrine genes and of type II pneumocyte genes, respectively. Retrospective analysis revealed a less favorable outcome for the adenocarcinomas with neuroendocrine gene expression. The diagnostic potential of expression profiling is emphasized by its ability to discriminate primary lung adenocarcinomas from metastases of extra-pulmonary origin. These results suggest that integration of expression profile data with clinical parameters could aid in diagnosis of lung cancer patients.
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| Overall design |
meyer-00191
Assay Type: Gene Expression
Provider: Affymetrix
Array Designs: HG_U95Av2
Organism: Homo sapiens (ncbitax)
Material Types: total RNA, synthetic_RNA, organism_part, whole_organism
Disease States: lung cancer, Normal
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| Citation(s) |
11707567 |
| Submission date |
Jun 10, 2016 |
| Last update date |
Dec 13, 2018 |
| Contact name |
Mervi Heiskanen |
| E-mail(s) |
mervi.heiskanen@nih.gov
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| Phone |
2402765175
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| Organization name |
NCI
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| Department |
CBIIT
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| Street address |
9609 Medical Center Drive, 1W378
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| City |
Rockville |
| State/province |
MD |
| ZIP/Postal code |
20850 |
| Country |
USA |
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| Platforms (1) |
| GPL8300 |
[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array |
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| Samples (254)
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| Relations |
| BioProject |
PRJNA325305 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE83227_RAW.tar |
718.0 Mb |
(http)(custom) |
TAR (of CEL, RPT, TXT) |
| GSE83227_caArray_meyer-00191.tar.gz |
1.3 Mb |
(ftp)(http) |
TAR |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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