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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 02, 2007 |
| Title |
Gene Signature for Aggression of Melanoma Metastases - Melanoma Metastasis (LeiFidler) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis.
Keywords: disease state analysis
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| Overall design |
parental cell line vs xenograft model
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| Contributor(s) |
Xu L, Shen SS, Hoshida Y, Subramanian A, Ross K, Brunet J, Wagner SN, Ramaswamy S, Mesirov JP, Hynes RO |
| Citation(s) |
18505921 |
| Submission date |
May 30, 2007 |
| Last update date |
Aug 10, 2018 |
| Contact name |
steve shen |
| E-mail(s) |
ssshen@mit.edu
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| Organization name |
MIT
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| Street address |
77 mass ave
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| City |
cambridge |
| State/province |
MA |
| ZIP/Postal code |
02139 |
| Country |
USA |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (39)
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| GSM195320 |
Melanoma metastatic cell line A375, P1, biol rep1 (LeiFidler) |
| GSM195321 |
Melanoma metastatic cell line A375, P2, biol rep2 (LeiFidler) |
| GSM195322 |
Melanoma metastatic cell line A375, P3, biol rep3 (LeiFidler) |
| GSM195323 |
Melanoma metastatic cell line A375, P4, biol rep4 (LeiFidler) |
| GSM195324 |
Melanoma metastatic cell line A375, P5, biol rep5 (LeiFidler) |
| GSM195325 |
Melanoma metastatic cell line A375, P6, biol rep6 (LeiFidler) |
| GSM195326 |
Melanoma metastatic cell line A375, P7, biol rep7 (LeiFidler) |
| GSM195327 |
Melanoma metastatic cell line A375, P8, biol rep8 (LeiFidler) |
| GSM195328 |
Melanoma metastatic cell line A375, P9, biol rep9 (LeiFidler) |
| GSM195329 |
Melanoma metastatic cell line A375, P10, biol rep10 (LeiFidler) |
| GSM195330 |
Melanoma xenograft, SM_Sub_A (LeiFidler) |
| GSM195331 |
Melanoma xenograft, SM_Sub_B (LeiFidler) |
| GSM195332 |
Melanoma xenograft, SM_Lung_A (LeiFidler) |
| GSM195333 |
Melanoma xenograft, SM_Lung_C (LeiFidler) |
| GSM195334 |
Melanoma xenograft, MEA2_Lung_A (LeiFidler) |
| GSM195335 |
Melanoma xenograft, MEA2_Lung_B (LeiFidler) |
| GSM195336 |
Melanoma xenograft, MEA3_Lung_A (LeiFidler) |
| GSM195337 |
Melanoma xenograft, MEA3_Lung_B (LeiFidler) |
| GSM195338 |
Melanoma xenograft, MEA3_Lung_C (LeiFidler) |
| GSM195339 |
Melanoma xenograft, MEC1_Lung_A (LeiFidler) |
| GSM195340 |
Melanoma xenograft, MEC2_Lung_A (LeiFidler) |
| GSM195341 |
Melanoma xenograft, MEA2_Sub_A (LeiFidler) |
| GSM195342 |
Melanoma xenograft, MEA2_Sub_B (LeiFidler) |
| GSM195343 |
Melanoma xenograft, MEC1_Sub_A (LeiFidler) |
| GSM195344 |
Melanoma xenograft, MEC1_Sub_B (LeiFidler) |
| GSM195345 |
Melanoma xenograft, MEC1_Sub_C (LeiFidler) |
| GSM195346 |
Melanoma xenograft, MEC2_Sub_A (LeiFidler) |
| GSM195347 |
Melanoma xenograft, MEC2_Sub_B (LeiFidler) |
| GSM195348 |
Melanoma xenograft, MEC2_Sub_C (LeiFidler) |
| GSM195349 |
Melanoma xenograft, MEA2_Lung_C (LeiFidler) |
| GSM195350 |
Melanoma xenograft, MEC1_Lung_C (LeiFidler) |
| GSM195351 |
Melanoma xenograft, MEC2_Lung_B (LeiFidler) |
| GSM195352 |
Melanoma xenograft, MED1_Lung_B (LeiFidler) |
| GSM195353 |
Melanoma xenograft, MED1_Lung_C (LeiFidler) |
| GSM195354 |
Melanoma xenograft, MEA3_Sub_A (LeiFidler) |
| GSM195355 |
Melanoma xenograft, MEA3_Sub_C (LeiFidler) |
| GSM195356 |
Melanoma xenograft, MED1_Sub_A (LeiFidler) |
| GSM195357 |
Melanoma xenograft, MED1_Sub_B (LeiFidler) |
| GSM195358 |
Melanoma xenograft, MED1_Sub_C (LeiFidler) |
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| Relations |
| BioProject |
PRJNA100701 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE7956_RAW.tar |
137.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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