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Series GSE7463 Query DataSets for GSE7463
Status Public on May 31, 2007
Title Expression data from 43 Ovarian tumors
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Gene expression profiles of malignant carcinomas surgically removed from ovarian cancer patients pre-treated with chemotherapy (neo-adjuvant) prior to surgery group into two distinct clusters. One group clusters with carcinomas from patients not pre-treated with chemotherapy prior to surgery (C-L) while the other clusters with non-malignant adenomas (A-L).
Although the C-L cluster is preferentially associated with p53 loss-of-function (LOF) mutations, the C-L cluster cancer patients display a more favorable clinical response to chemotherapy as evidenced by enhanced long-term survivorships.
Keywords: Patient Tumor Samples
 
Overall design A set of 43 ovarian tumors was obtained from the Ovarian Cancer Institute (Atlanta). Tissue was collected at the time of surgery and preserved in RNAlater (Ambion, Austin, TX) within one minute of collection. Labeled probe was hybridized to the Affymetrix HG-U95Av2 arrays.
Web link http://ovariancancerinstitute.org/
 
Contributor(s) Moreno CS, McDonald JF
Citation(s) 17505532, 19077237
Submission date Apr 05, 2007
Last update date Jun 07, 2019
Contact name Nathan J. Bowen
E-mail(s) nbowen@cau.edu
Phone 4048808158
Organization name Clark Atlanta University
Department Center for Cancer Research and Therapeutic Development
Lab Cancer Development and Evolution
Street address 223 James P Brawley Drive
City Atlanta
State/province GA
ZIP/Postal code 30314
Country USA
 
Platforms (1)
GPL8300 [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Samples (43)
GSM180626 Adenoma patient 125
GSM180627 Adenoma patient 132
GSM180628 Adenoma patient 146
Relations
BioProject PRJNA100209

OV-CC-GCRMA-unlog header descriptions
Sample ID
NAME
ADENOMA_125 GSM180626
ADENOMA_132 GSM180627
ADENOMA_146 GSM180628
ADENOMA_159 GSM180629
ADENOMA_172 GSM180630
ADENOMA_221 GSM180631
ADENOMA_300 GSM180632
ADENOMA_64 GSM180633
ADENOMA_77A GSM180634
ADENOMA_97 GSM180635
CANCER_183 GSM180636
CANCER_196 GSM180637
CANCER_2 GSM180638
CANCER_204 GSM180639
CANCER_212 GSM180640
CANCER_23 GSM180641
CANCER_4 GSM180642
CANCER_66 GSM180643
CANCER_99 GSM180644
CC_150 GSM180645
CC_184 GSM180646
CC_187 GSM180647
CC_199 GSM180648
CC_253 GSM180649
CC_255 GSM180650
CC_259 GSM180651
CC_269 GSM180652
CC_272 GSM180653
CC_279 GSM180654
CC_286 GSM180655
CC_29 GSM180656
CC_303 GSM180657
CC_310 GSM180658
CC_311 GSM180659
CC_312 GSM180660
CC_314 GSM180661
CC_325 GSM180662
CC_326 GSM180663
CC_338 GSM180664
CC_36 GSM180665
CC_76 GSM180666
CC_9 GSM180667
CC_94 GSM180668

Data table
Sample ID NAME ADENOMA_125 ADENOMA_132 ADENOMA_146 ADENOMA_159 ADENOMA_172 ADENOMA_221 ADENOMA_300 ADENOMA_64 ADENOMA_77A ADENOMA_97 CANCER_183 CANCER_196 CANCER_2 CANCER_204 CANCER_212 CANCER_23 CANCER_4 CANCER_66 CANCER_99 CC_150 CC_184 CC_187 CC_199 CC_253 CC_255 CC_259 CC_269 CC_272 CC_279 CC_286 CC_29 CC_303 CC_310 CC_311 CC_312 CC_314 CC_325 CC_326 CC_338 CC_36 CC_76 CC_9 CC_94
100_g_at Hs.377992\!Rab geranylgeranyltransferase, alpha subunit\!RABGGTA\!||RABGGTA||Rab geranylgeranyltransferase, alpha subunit||RAB GERANYLGERANYL TRANSFERASE, ALPHA SUBUNIT||Rab geranylgeranyltransferase, alpha subunit isoform a||Rab geranylgeranyltransferase, alpha subunit isoform b||\!5875\!Y08200\!14q11.2\!14\!NA\!molecular function| transferase activity | inferred from electronic annotation|GO:0016740//molecular function| protein prenyltransferase activity | inferred from electronic annotation |GO:0008318//molecular function| RAB-protein geranylgeranyltransferase activity | traceable author statement |GO:0004663//biological process| protein amino acid prenylation | inferred from electronic annotation|GO:0018346//biological process| visual perception | traceable author statement |GO:0007601//biological process| protein modification | traceable author statement |GO:0006464\! 11.1792 13.8308 13.2148 12.0421 13.91 13.7332 15.9282 19.1727 12.7707 13.1442 12.9953 13.3032 20.1625 13.499 12.2782 17.3359 19.6149 12.7783 17.1959 13.0214 13.938 25.1393 21.212 13.0907 12.7116 13.0004 12.014 12.6378 13.7781 13.237 27.2021 11.9973 11.8555 12.9585 13.0146 16.8075 13.5059 12.7603 10.5924 16.7262 40.1454 12.3716 12.8673
1000_at Hs.861\!mitogen-activated protein kinase 3\!MAPK3\!||2.7.1.-||MAPK3||PRKM3||p44ERK1||p44MAPK||mitogen-activated protein kinase 3||PROTEIN KINASE, MITOGEN-ACTIVATED, 3||EXTRACELLULAR SIGNAL-REGULATED KINASE 1||protein kinase, mitogen-activated 3 (MAP kinase 3; p44)||\!5595\!X60188\!16p12-p11.2\!16\!NA\!molecular function| transferase activity | inferred from electronic annotation|GO:0016740//molecular function| ATP binding | non-traceable author statement |GO:0005524//molecular function| MAP kinase activity | non-traceable author statement |GO:0004707//molecular function| protein serine/threonine kinase activity | inferred from electronic annotation |GO:0004674//biological process| protein amino acid phosphorylation | inferred from electronic annotation|GO:0006468//biological process| regulation of cell cycle | non-traceable author statement |GO:0000074\! 164.404 199.584 197.303 150.093 161.927 192.867 133.792 178.451 86.0326 92.2678 70.6555 77.614 84.0214 71.0974 216.749 42.6145 85.9617 47.9267 119.036 171.459 220.402 125.728 113.476 92.4772 57.5425 116.092 100.497 120.445 225.21 173.546 87.3544 132.768 224.521 144.929 100.793 188.362 214.669 176.526 157.311 181.501 237.845 51.0763 132.562
1001_at Hs.78824\!tyrosine kinase with immunoglobulin and epidermal growth factor homology domains\!TIE\!||JTK14||2.7.1.112||TIE1||TIE||PROTEIN RECEPTOR TYROSINE KINASE TIE 1||TYROSINE KINASE WITH IMMUNOGLOBULIN AND EGF FACTOR HOMOLOGY DOMAINS||tyrosine kinase wi 7.622 10.7791 8.12063 7.33729 8.03048 10.5784 8.9732 8.63284 6.83277 8.2709 7.4764 7.9183 8.9715 8.1834 7.69411 6.78941 7.9994 7.16689 7.82875 8.05014 8.45229 8.23267 8.28242 8.12329 7.5979 9.48485 15.9044 8.03986 8.09352 8.03346 6.75263 7.37351 15.8253 8.42038 8.08326 12.9271 9.64035 7.97131 8.07355 8.61008 8.11969 7.49846 7.07784
1002_f_at Hs.418127\!cytochrome P450, family 2, subfamily C, polypeptide 9\!CYP2C9\!||CYP2C10||P450IIC9||CPC9||CYP2C9||1.14.14.1||microsomal monooxygenase||xenobiotic monooxygenase||P450 MP-4||flavoprotein-linked monooxygenase||P450 PB-1||CYTOCHROME P450, SUBFAMILY 23.3294 25.3046 24.814 21.1858 23.9409 25.5851 28.8027 29.465 22.781 25.3402 22.2734 24.5418 30.1925 25.2323 25.7485 27.2675 26.7461 24.0655 24.7475 27.0574 25.9294 25.4223 25.3278 33.5259 23.7189 24.2579 19.9769 23.3966 24.9795 24.8017 25.1195 21.9111 21.5601 25.442 23.3981 23.3303 25.3476 23.3858 24.7266 20.8282 24.8143 30.5289 24.7489
1003_s_at Hs.113916\!Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)\!BLR1\!||CXCR5||MDR15||BLR1||monocyte-derived receptor 15||CHEMOKINE (C-X-C) RECEPTOR 5||C-X-C chemokine receptor type 5||Burkitt lymphoma receptor 1 isoform 4.54583 4.85413 4.68279 4.20762 4.61962 4.85644 4.94186 5.36389 4.54135 4.76975 5.00031 4.75339 5.14484 4.76133 4.38696 5.93447 4.8882 4.63924 4.77263 4.65984 4.8648 4.80968 4.80361 4.78802 4.56869 4.61507 4.25794 4.45959 4.95236 4.69868 4.52056 4.36881 4.13517 4.40262 4.65219 4.41063 4.82642 4.57637 4.69205 4.34868 4.66143 5.51102 4.6645
1004_at Hs.113916\!Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)\!BLR1\!||CXCR5||MDR15||BLR1||monocyte-derived receptor 15||CHEMOKINE (C-X-C) RECEPTOR 5||C-X-C chemokine receptor type 5||Burkitt lymphoma receptor 1 isoform 28.9411 31.4486 30.4204 25.8172 30.3442 33.9647 33.024 44.7424 29.681 32.1872 29.6076 31.0067 39.1072 31.8055 26.8945 36.9236 33.965 30.0001 33.8494 32.058 36.1118 32.231 30.63 30.8435 38.952 32.6209 27.0159 30.7188 30.9423 33.501 28.7334 26.707 27.712 27.9354 29.9885 28.244 30.5552 29.3902 31.0754 28.9698 31.9812 39.9432 31.581
1005_at Hs.171695\!dual specificity phosphatase 1\!DUSP1\!||PTPN10||3.1.3.48||CL100||MKP1||MKP-1||DUSP1||3.1.3.16||HVH1||DUAL-SPECIFICITY PHOSPHATASE 1||dual specificity phosphatase 1||PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE, 10||MAP KINASE PHOSPHATASE 1|| 460.387 62.637 288.708 171.292 80.9217 249.016 110.68 58.5984 60.9335 44.7385 33.2234 58.845 24.9191 23.141 49.2051 88.0209 50.957 26.1656 29.7633 38.4207 57.4039 41.0194 22.7182 1698.03 833.158 365.765 878.308 47.9058 1374.75 28.2318 173.972 26.7065 24.4423 26.6309 11.7534 162.586 11.115 30.8412 924.584 2182.3 39.1902 67.6094 217.634
1006_at Hs.2258\!matrix metalloproteinase 10 (stromelysin 2)\!MMP10\!||STMY2||3.4.24.22||MMP10||SL-2||transin 2||STROMELYSIN II||matrix metalloproteinase 10 preproprotein||matrix metalloproteinase 10 (stromelysin 2)||\!4319\!X07820\!11q22.3\!11\!Proteins of the m 9.63627 11.0729 10.3347 9.15354 9.92369 11.01 11.2237 14.6202 10.0289 11.242 9.96971 11.9764 13.1973 10.9323 11.8497 20.6791 13.4869 136.47 10.4376 10.406 11.596 10.9498 11.3314 10.5003 10.1315 9.99571 8.3489 9.82236 10.7941 10.8002 10.4837 9.22236 8.07909 9.52585 10.2945 9.29982 10.7864 9.89743 10.5141 90.5101 14.507 19.6127 11.2932
1007_s_at Hs.423573\!discoidin domain receptor family, member 1 /// discoidin domain receptor family, member 1\!DDR1\!||NTRK4||TRKE||2.7.1.112||MCK10||RTK6||EDDR1||CAK||DDR1||CD167||neuroepithelial tyrosine kinase||EPITHELIAL-SPECIFIC RECEPTOR KINASE||cell adhesion 217.838 133.762 289.846 330.857 398.036 364.364 255.129 367.258 574.652 241.599 516.944 431.427 1066.11 264.126 1004.28 771.296 585.266 364.688 527.061 271.485 239.952 362.921 401.979 164.664 560.286 625.645 332.603 231.207 341.723 573.371 530.935 251.798 159.106 246.567 372.386 244.198 260.703 309.035 197.736 554.579 1612.54 102.775 632.616
1008_f_at Hs.439523\!protein kinase, interferon-inducible double stranded RNA dependent\!PRKR\!||2.7.1.-||PRKR||EIF2AK1||PKR||interferon-inducible elF2alpha kinase||PROTEIN KINASE, INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-ACTIVATED||protein kinase, interferon-induc 55.1376 63.4877 60.1614 54.1903 61.4748 44.6559 49.9815 61.472 111.151 64.9468 71.7455 90.251 153.258 86.071 43.6801 87.0419 133.933 80.0286 61.4005 64.4681 68.851 78.1181 78.5041 112.428 59.5481 93.2166 55.6309 86.2847 60.7608 106.207 77.5888 59.2733 53.7469 45.7129 61.0853 51.9294 48.1729 58.6052 52.6235 67.1802 43.6905 234.688 73.2109
1009_at Hs.256697\!histidine triad nucleotide binding protein 1\!HINT1\!||PRKCNH1||HINT1||PKCI1||PKCI-1||PROTEIN KINASE C-INTERACTING PROTEIN 1||histidine triad nucleotide binding protein 1||Histidine triad nucleotide-binding protein (protein kinase C inhibitor 1)||\!3094\!U51004\!5q31.2\!5\!NA\!NA\! 1331.93 1256.76 1422.29 1320.47 1286.13 1634.03 1461.49 1597.53 2313.38 1381.67 1009.85 2325.81 1705.67 1479.07 1418.5 1916.08 2608.29 1965.91 1397.87 1542.17 1236.75 1423.42 1361.22 936.261 1440.89 1605.96 1391.04 1020.43 1406.87 1154.85 2128.6 1489.8 1068.58 1252.37 1576.22 1248.76 1364.71 1364.33 1424.27 1523.03 1769.55 2259.51 1991.58
101_at Hs.439530\!dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4\!DYRK4\!||DYRK4||dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4||\!8798\!Y09305\!12p13.32\!12\!NA\!molecular function| pkinase;protein kinase activity;3.3e-61 | extended:Unknown|GO:0004672//molecular function| transferase activity | inferred from electronic annotation |GO:0016740//molecular function| ATP binding | non-traceable author statement |GO:0005524//molecular function| protein-tyrosine kinase activity | inferred from electronic annotation |GO:0004713//molecular function| protein serine/threonine kinase activity | non-traceable author statement |GO:0004674//biological process| protein amino acid phosphorylation | non-traceable author statement|GO:0006468\! 64.9829 112.828 98.71 74.3671 106.026 81.311 98.6567 90.3774 71.5725 75.5103 47.47 103.207 83.673 122.507 52.1336 31.178 90.0384 107.545 55.0618 83.1451 124.231 84.7131 84.4514 82.6512 74.5295 51.4981 67.3636 84.233 105.255 85.4675 39.8822 74.8454 86.1915 78.8858 47.9378 85.1923 102.621 78.6423 82.2496 79.2155 47.1455 127.743 57.0694
1010_at Hs.57732\!mitogen-activated protein kinase 11\!MAPK11\!||SAPK2B||P38BETA2||p38-BETA-2||PRKM11||MAPK11||stress-activated protein kinase-2b||STRESS-ACTIVATED PROTEIN KINASE 2B||mitogen-activated protein kinase 11||mitogen-activated protein kinase p38-2||PRO 6.41429 7.1209 6.78785 6.10432 6.50363 7.11684 7.28517 8.22971 6.59581 7.03444 6.47365 6.84369 8.02612 7.00651 6.11334 9.46489 7.33084 6.64732 6.81419 6.74585 7.16049 6.99571 6.99244 6.79053 6.55353 6.6146 5.85639 6.44764 6.94393 6.88477 6.88297 6.52572 5.70854 6.5199 6.7001 6.24575 6.98443 6.64257 6.84545 6.44404 6.81383 8.71657 6.72203
1011_s_at Hs.79474\!tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide\!YWHAE\!||MDCR||14-3-3-EPSILON||14-3-3E||MDS||KCIP-1||YWHAE||14-3-3 epsilon||14-3-3 PROTEIN, EPSILON ISOFORM||protein kinase C inhibitor protein-1||mitoc 1443.37 1059.61 1197.27 1487.79 1077.51 1124.54 768.368 392.023 2237.42 978.198 2361.8 1803.95 457.879 1687.48 875.238 458.25 250.414 1778.1 2015.23 1266.6 1295.53 1158.47 1257.35 783.855 1329.2 2287.4 1699.96 1084.24 1282.63 2023.06 620.798 990.248 985.999 1037.22 1224.68 710.355 1149.62 1534.04 1534.06 1142.04 933.535 534.541 1117.5
1012_at Hs.203475\!p300/CBP-associated factor\!PCAF\!||PCAF||P/CAF||p300/CBP-ASSOCIATED FACTOR||CREBBP-associated factor||\!8850\!U57317\!3p24\!3\!CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or d 12.015 12.4291 11.8891 10.7054 11.3832 12.6026 12.6422 16.4248 15.2695 15.1062 11.2309 12.1895 20.0289 12.4416 10.4197 20.0565 13.8734 11.7152 11.9817 12.0015 14.3496 12.5046 12.4097 12.081 11.5 11.7471 9.9617 11.3043 12.3125 14.9413 11.9088 10.5758 9.81464 11.1832 11.6464 10.5404 12.3403 12.494 17.8846 11.9623 12.0829 47.0047 12.9188
1013_at Hs.167700\!SMAD, mothers against DPP homolog 5 (Drosophila)\!SMAD5\!||Dwfc||JV5-1||MADH5||SMAD5||MAD homolog 5||SMA- and MAD-related protein 5||MAD, mothers against decapentaplegic homolog 5 (Drosophila)||mothers against decapentaplegic, drosophila, homol 56.6891 33.6985 28.5847 37.173 31.2774 17.1212 19.5344 28.2266 224.407 78.9126 63.7625 39.5441 43.6436 35.8612 25.4404 34.6665 40.2745 74.888 75.477 38.64 30.2162 34.3639 21.6177 32.5911 39.3366 56.7824 25.3102 31.0831 33.3868 43.3156 48.2073 34.8509 34.2251 29.5249 33.2941 18.962 22.4745 37.2658 66.545 50.309 19.3308 60.9321 41.3438
1014_at Hs.290921\!polymerase (DNA directed), gamma\!POLG\!||POLG||POLG-ALPHA||POLG1||2.7.7.7||POLGA||PEO||POLG, CATALYTIC SUBUNIT||POLYMERASE, DNA, GAMMA-1||polymerase (DNA directed), gamma||\!5428\!U60325\!15q25\!15\!NA\!molecular function| transferase activity 76.7778 113.003 92.7661 98.1679 101.444 81.0832 111.337 101.486 96.518 116.138 82.2319 131.105 104.371 157.137 124.146 183.936 200.684 196.581 161.233 100.814 72.0519 102.217 94.232 135.403 104.194 130.654 118.617 107.967 100.512 94.5182 126.495 110.263 109.387 84.0743 104.213 109.87 111.363 114.803 87.631 94.163 308.169 47.6098 105.33
1015_s_at Hs.36566\!LIM domain kinase 1\!LIMK1\!||2.7.1.-||LIMK1||LIM KINASE||LIM motif-containing protein kinase||LIM domain kinase 1||LIM domain kinase 1 isoform 1||LIM domain kinase 1 isoform dLIMK||\!3984\!U62293\!7q11.23\!7\!There are approximately 40 known eu 11.167 12.6999 12.0263 12.0799 11.307 12.6458 12.8515 15.3437 11.7398 12.7463 11.561 12.242 20.4659 12.4814 11.2926 19.4608 14.2314 12.0184 12.1509 11.7835 12.6294 12.4644 12.4645 12.0918 11.862 11.8968 10.5824 11.5449 12.3954 12.0062 11.9098 10.8409 10.8222 11.6704 11.8983 11.3946 12.8074 11.6403 12.1888 11.2408 12.2127 14.2978 12.0903
1016_s_at Hs.336046\!interleukin 13 receptor, alpha 2\!IL13RA2\!||IL-13R||IL13BP||IL13RA2||IL-13 receptor||interleukin 13 binding protein||INTERLEUKIN 13 RECEPTOR, ALPHA-2||interleukin 13 receptor, alpha 2||interleukin 13 receptor alpha 2 chain||interleukin 13 rece 4.51124 4.98842 4.79248 4.31258 4.66568 5.02252 5.04965 6.03478 4.63119 4.98539 4.57636 4.85033 5.96103 4.97338 4.33139 7.22599 5.32692 4.711 4.80912 4.76122 5.12126 5.00294 4.98126 4.78686 4.69424 4.65292 4.15065 4.55558 4.90934 4.90812 4.76696 4.29222 4.02347 4.52745 4.76671 4.42877 4.95047 4.64462 4.84071 7.62397 4.81989 6.99279 4.86813
1017_at Hs.445052\!mutS homolog 6 (E. coli)\!MSH6\!||HNPCC5||MSH6||G/T mismatch-binding protein||mutS (E. coli) homolog 6||mutS homolog 6 (E. coli)||MutS, E. COLI, HOMOLOG OF, 6||GTBP COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5||\!2956\!U73737\!2p16\!2\!NA\!molecular function| ATP binding | inferred from electronic annotation|GO:0005524//molecular function| damaged DNA binding | traceable author statement |GO:0003684//cellular component| nucleus | inferred from electronic annotation|GO:0005634//biological process| mismatch repair | traceable author statement|GO:0006298\! 47.7702 39.7647 46.1206 41.5746 17.5278 26.8277 26.9482 21.8305 28.9713 43.9209 17.1211 20.7135 21.7743 21.8178 16.2097 26.3386 27.0902 32.8547 25.4243 45.4321 27.4692 18.744 20.6271 17.9592 20.932 14.7707 15.9023 22.9685 32.4995 28.8742 25.8018 33.0299 52.6208 29.7581 34.8529 16.8577 31.6566 39.0401 40.4334 46.3375 34.4406 65.168 54.8119

Total number of rows: 12625

Table truncated, full table size 8556 Kbytes.




Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7463_RAW.tar 93.1 Mb (http)(custom) TAR (of CEL)

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