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| Status |
Public on Oct 14, 2015 |
| Title |
Molecular insight into AL cells and their subsequent dedifferentiation to primitive cell types with multilineage potency |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The sequential adipogenic differentiation and dedifferentiation processes resulted in novel stem cells that proliferated faster and retained multilineage potency; however, the mechanism underlying this cross-talk remained to be determined. In this context, we identified a number of differentially expressed genes during these processes.
Gene expression profiling was performed to obtain a deeper molecular insight into AL cells and their subsequent dedifferentiation to primitive cell types with multilineage potency. GeneChips were generated for PDMSCs, AL cells and DePDMSCs from 3 donors. We selected numerous genes which were differentially expressed in the processes.
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| Overall design |
Expression profiling was performed for 9 samples (n = 3 donors) subdivided into 3 groups: 3X (PDMSCs), 3X (AL cells) and 3X (DePDMSCs P3) using [PrimeView] Affymetrix Human Gene Expression Array.
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| Contributor(s) |
Hu C, Yu Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 13, 2015 |
| Last update date |
Aug 23, 2018 |
| Contact name |
Chenxia Hu |
| E-mail(s) |
11318093@zju.edu.cn
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| Organization name |
Zhejiang University
|
| Department |
First Affiliated Hospital; Zhejiang University
|
| Street address |
School of Medicine; First Affiliated Hospital; Zhejiang University
|
| City |
Hangzhou |
| State/province |
Zhejiang |
| ZIP/Postal code |
571 |
| Country |
China |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA298595 |
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