|
| Status |
Public on Aug 06, 2018 |
| Title |
Transcriptional dysregulation of inflammatory/immune pathways after active vaccination against Huntington’s disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Transcriptome profiling of spleens from the triple peptide-immunized cohort showed substantial HD-specific differences including differential activation of genes associated with innate immune responses, absence of negative feedback control of gene expr
|
| |
|
| Overall design |
HD R6/1, zQ175 and +/+ mice were immunized with a combination of 3 peptides from HTTExon1. Spleens were collected 10 days after final boost. Transcriptome was determined by Affimetrix chip. Data analyzed by GSEA.
|
| |
|
| Contributor(s) |
Ramsingh AI, Manley K, Reilly AA, Messer A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 06, 2015 |
| Last update date |
Aug 07, 2018 |
| Contact name |
Andrew Arthur Reilly |
| E-mail(s) |
aar022003@yahoo.com
|
| Organization name |
Wadsworth Cntr, NYS Dept of Health
|
| Department |
Genetics
|
| Lab |
Rm CMS 2004
|
| Street address |
150 New Scotland Ave
|
| City |
Albany |
| State/province |
NY |
| ZIP/Postal code |
12208 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (29)
|
|
| Relations |
| BioProject |
PRJNA292125 |
Less...
More...