|
| Status |
Public on May 15, 2015 |
| Title |
caArray_golub-00142: Gene expression correlates of clinical prostate cancer behavior |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Prostate tumors are among the most heterogeneous of cancers, both histologically and clinically. Microarray expression analysis was used to determine whether global biological differences underlie common pathological features of prostate cancer and to identify genes that might anticipate the clinical behavior of this disease. While no expression correlates of age, serum prostate specific antigen (PSA), and measures of local invasion were found, a set of genes was identified that strongly correlated with the state of tumor differentiation as measured by Gleason score. Moreover, a model using gene expression data alone accurately predicted patient outcome following prostatectomy. These results support the notion that the clinical behavior of prostate cancer is linked to underlying gene expression differences that are detectable at the time of diagnosis.
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| |
|
| Overall design |
golub-00142
Assay Type: Gene Expression
Provider: Affymetrix
Array Designs: HG_U95Av2
Organism: Homo sapiens (ncbitax)
|
| |
|
| Citation(s) |
12086878 |
| Submission date |
May 14, 2015 |
| Last update date |
Dec 13, 2018 |
| Contact name |
Mervi Heiskanen |
| E-mail(s) |
mervi.heiskanen@nih.gov
|
| Phone |
2402765175
|
| Organization name |
NCI
|
| Department |
CBIIT
|
| Street address |
9609 Medical Center Drive, 1W378
|
| City |
Rockville |
| State/province |
MD |
| ZIP/Postal code |
20850 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL8300 |
[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array |
|
| Samples (102)
|
|
| Relations |
| BioProject |
PRJNA283999 |
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