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| Status |
Public on Jun 30, 2009 |
| Title |
HRI Protects Erythroid Precursors in iron deficiency and beta-Thalassemia by Maintaining GATA-1 and Fog-1 Expression |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Heme-regulated eIF2α kinase (HRI) is essential for the survival of erythroid precursors in iron and heme deficiency and it also plays a protective role in red blood cell diseases of erythroid protoporphyria and β-thalassemia. In this study, we demonstrated for the first time the impairment of GATA-1 and Fog-1 expressions in iron deficiency and the impairment of GATA-1 expression in β-thalassemia. Furthermore, HRI is necessary to maintain the GATA-1/Fog-1 induced functions in erythroid differentiation, cell cycle and cell survival by sustaining both expressions of GATA-1 and Fog-1 in iron deficiency and in β-thalassemia.
Keywords: Genetic modification
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| Overall design |
Three replicates of gene chip profiling were performed for each condition, Wt+Fe, Wt-Fe, Ko+Fe and Ko-Fe.
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| Contributor(s) |
Liu S, Bhattacharya S, Han A, Suragani RN, Zhao W, Fry R, Weiss MJ, Chen J |
| Citation(s) |
18665838 |
| Submission date |
Jan 19, 2007 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Sanchita Bhattacharya |
| E-mail(s) |
SBhattacharya@lbl.gov
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| Phone |
510-486-6881
|
| Organization name |
MIT
|
| Street address |
1 Cyclotron Rd
|
| City |
Berkely |
| State/province |
CA |
| ZIP/Postal code |
94720 |
| Country |
USA |
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| Platforms (2) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA99213 |
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