|
| Status |
Public on Jan 25, 2007 |
| Title |
Foxp3 ablation in peripheral mature regulatory T cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of Foxp3 ablated peripheral regulatory T cells. Regulatory T cells require the expression of the transcription factor Foxp3 for thymic development. It is not known whether continuous expression of Foxp3 is required for the maintained function of mature regulatory T cells in the periphery. Results indicate changes to the regulatory T cell developmental program in the absence of Foxp3.
Keywords: genetic modification
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| |
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| Overall design |
Compare Cre recombinase treated peripheral regulatory T cells possessing a Cre sensitive Foxp3 locus to Cre treated regulatory T cells with a wild type Foxp3 locus. Cre exposure is observed via the Cre sensitive expression of the yellow flourescent protein molecule.
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| |
|
| Contributor(s) |
Williams LM, Rudensky AY |
| Citation(s) |
17220892 |
| Submission date |
Jan 08, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Alexander Rudensky |
| Organization name |
University of Washington
|
| Department |
Immunology
|
| Street address |
1959 Pacific St
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98195 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA99057 |
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