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| Status |
Public on Dec 06, 2007 |
| Title |
Expression data from olfactory epithelium of Harlequin mutant mice compared to littermate controls |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Microarray analysis of gene expression in the olfactory epithelium of Harlequin mouse as a model of oxidative-stress induced neurodegeneration of olfactory sensory neurons
Keywords: comparison of gene expression level in unperturbed tissue of mutant vs. control mouse
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| |
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| Overall design |
Olfactory epithelium from Harlequin mutant mice and littermate control mice was microdissected for RNA extraction and hybridization on Affymetrix microarrays. We compared levels of gene expression in 6-month old mice to begin to identify mechanisms of oxidative-stress induced neurodegeneration and to correlate the cellular changes that we observed in the olfactory epithelium by using histology and immunohistochemistry with gene expression changes.
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| Contributor(s) |
Vaishnav RA, Getchell ML, Huang L, Hersh MA, Stromberg AJ, Getchell TV |
| Citation(s) |
17868149 |
| Submission date |
Dec 08, 2006 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Marilyn L. Getchell |
| E-mail(s) |
mgetch@uky.edu
|
| Organization name |
University of Kentucky
|
| Department |
Anatomy and Neurobiology
|
| Lab |
Sanders-Brown Center on Aging
|
| Street address |
800 South Limestone St.
|
| City |
Lexington |
| State/province |
KY |
| ZIP/Postal code |
40536-0230 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| GSM149360 |
6 month old adult male mutant mouse Hq/Y, biol rep1 |
| GSM149361 |
6 month old adult male mutant mouse Hq/Y, biol rep2 |
| GSM149362 |
6 month old adult male mutant mouse Hq/Y, biol rep3 |
| GSM149363 |
6 month old adult male littermate control +/Y, biol rep1 |
| GSM149364 |
6 month old adult male littermate control +/Y, biol rep2 |
| GSM149365 |
6 month old adult male littermate control +/Y, biol rep3 |
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| Relations |
| BioProject |
PRJNA98731 |
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