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| Status |
Public on Dec 02, 2006 |
| Title |
Comparison between gene expression in heart from Emd KO and control mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The present research is devoted to the identification of gene(s) severely affected by EMD mutations, leading to striated muscle laminopathies and more specifically the cardiomyopathy. For this purpose, we developped a large-scale gene expression approach on heart and skeletal tissues from Emd KO mouse model.
Keywords: disease state modification
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| Overall design |
In the project presented here we performed differential expression in heart from a mouse model of EDMD: a Emd KO mouse created via homologous recombination by Y.Hayashi in Japan (Ozawa, 2006). The emd knock-out mouse showed significantly delayed PR time, that could correspond to impaired atrial-ventricle node conduction. Genes were identified as differentially expressed if they met a false discovery rate threshold of 0.05 in a two-sample t-test (q-value) and showed at least a two-fold difference in expression independent of absolute signal intensity.
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| Contributor(s) |
Muchir a, Pavlidis p, Hayashi yk, Worman hj |
| Citation(s) |
17567779 |
| Submission date |
Nov 29, 2006 |
| Last update date |
Feb 11, 2019 |
| Contact name |
antoine Muchir |
| E-mail(s) |
am2434@columbia.edu
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| Phone |
212 305 4088
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| Organization name |
columbia university
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| Department |
Medicine
|
| Street address |
630W 168th street
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10032 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (14)
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| Relations |
| BioProject |
PRJNA99709 |
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