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| Status |
Public on Oct 01, 2015 |
| Title |
Gene expression of mouse intestine treated with azoxymethane and/or St. John's wort |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The aim of this study was to examine the effects of dietary supplementation of St John’s wort extract on azoxymethane-induced colorectal carcinogenesis in mice. Microarray data showed atttenuation of NF-kB and ERK-mediated pathway in colon epithelium by St. Jone's wort suggesting that the anti-inflammatory effect is a possible cancer-preventing mechanism induced by St. Jone's wort.
Gene expression will be compared between mice with the control vs. St. Jone's wort.
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| |
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| Overall design |
Six-condition experiment, CSN vs SSN vs CAN vs SAN vs CAT vs.SAT Biological replicates: 3CSN, 3SSN, 3CAN, 3SAN, 3CAT and 3SAT samples.
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| |
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| Contributor(s) |
Manna SK, Tanaka N, Cai Y, Matsubara T, Gonzalez FJ |
| Citation(s) |
26069204 |
| Submission date |
Apr 07, 2014 |
| Last update date |
Jan 12, 2017 |
| Contact name |
yan cai |
| E-mail(s) |
yan.cai@nih.gov
|
| Phone |
3014020062
|
| Organization name |
NIH
|
| Department |
NCI
|
| Lab |
LM
|
| Street address |
9000 rockville pike
|
| City |
bethesda |
| State/province |
maryland |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA243931 |
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