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| Status |
Public on Oct 16, 2006 |
| Title |
p53 family members in myogenic differentiation and rhabdomyosarcoma development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The p53 family comprises the tumor suppressor p53 and the structural homologs p63 and p73. How the three family members cooperate in tumor suppression remains unclear. Here, we report different but complementary functions of the individual members for regulating retinoblastoma protein (RB) function during myogenic differentiation. Whereas p53 transactivates the retinoblastoma gene, p63 and p73 induce the cyclin-dependent kinase inhibitor p57 to maintain RB in an active, hypophosphorylated state. DeltaNp73 inhibits these functions of the p53 family in differentiation control, prevents myogenic differentiation, and enables cooperating oncogenes to transform myoblasts to tumorigenicity. DeltaNp73 is frequently overexpressed in rhabdomyosarcoma and essential for tumor progression in vivo. These findings establish differentiation control as a key tumor suppressor activity of the p53 family.
Keywords: oligonucleotide
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| Overall design |
DeltaNp73 alpha expressing C2C12 myoblasts examined 6 and 24 hours after shifting the cells to a differentiation medium.
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| |
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| Contributor(s) |
Cam H, Griesman H, Burek C, Stiewe T |
| Citation(s) |
17045206 |
| Submission date |
Aug 03, 2006 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Christof Burek |
| E-mail(s) |
christof.burek@mail.uni-wuerzburg.de
|
| Phone |
++49 (0)931 20147696
|
| Organization name |
Universitaet Wuerzburg
|
| Department |
Pathologie
|
| Lab |
Rosenwald
|
| Street address |
Josef-schneider-Str. 2
|
| City |
Wuerzburg |
| ZIP/Postal code |
97080 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (6)
|
| GSM124854 |
p53 family members in myogenic differentiation mock 0 h |
| GSM124864 |
p53 family members in myogenic differentiation DeltaNp73 0 h |
| GSM124865 |
p53 family members in myogenic differentiation DeltaNp73 6h |
| GSM124866 |
p53 family members in myogenic differentiation mock 24 h |
| GSM124867 |
p53 family members in myogenic differentiation DeltaNp72 24h |
| GSM124868 |
p53 family members in myogenic differentiation mock 6 h |
|
| Relations |
| BioProject |
PRJNA96121 |
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