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| Status |
Public on Jul 27, 2007 |
| Title |
Expression profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to characterise for the first time the human adult Down syndrome brain
Keywords: disease state analysis
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| Overall design |
RNA extracted from human postmortem brain tissue from adult subjects with Down syndrome and healthy controls was hybridised to Affymetrix HG-U133A GeneChips to identify differentially expressed genes in the disease state.
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| Contributor(s) |
Bahn S, Lockstone HE, Wiseman Harris LJ, Swatton JE, Wayland MT, Jackson ES |
| Citation(s) |
17950572 |
| Submission date |
Jul 25, 2006 |
| Last update date |
Apr 27, 2020 |
| Contact name |
Sabine Bahn |
| E-mail(s) |
sb209@cam.ac.uk
|
| Organization name |
University of Cambridge
|
| Lab |
Cambridge Centre for Neuropsychiatric Research
|
| Street address |
Tennis Court Road
|
| City |
Cambridge |
| ZIP/Postal code |
CB2 1QT |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (15)
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| GSM123264 |
brain_Down_syndrome_sampleid_jg1734 |
| GSM123265 |
brain_Down_syndrome_sampleid_jg1737 |
| GSM123266 |
brain_Down_syndrome_sampleid_jg1738 |
|
| Relations |
| BioProject |
PRJNA96183 |
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