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| Status |
Public on Jul 21, 2006 |
| Title |
Myositis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Idiopathic inflammatory myopathies (polymyositis and dermatomyositis) are heterogeneous group of muscle disorders of unknown etiology.The pathogenic pathways responsible for muscle fiber damage and dysfunction in myositis are not currently well defined. Identification of such pathways may help to design novel therapeutic interventions and also help to develop diagnostic tests.
Keywords: Development or differentiation design
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| Overall design |
Muscle biopsies from a separate group of 5 adult untreated female dermatomyositis (PHM-DM samples) patients were profiled and compared to muscle tissue of normal human healthy volunteers (FSH-NHM samples) to define molecular pathways in muscle of myositis patients. Confirm and map key pathway members to specific cell types in the muscle tissue of patients and controls using RT-PCR, Western blotting and Immunolocalization.
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| Contributor(s) |
Kanneboyina N |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 21, 2006 |
| Last update date |
Oct 09, 2019 |
| Contact name |
Eric P Hoffman |
| E-mail(s) |
ericphoffman@gmail.com
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| Organization name |
Binghamton University - SUNY
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| Department |
Pharmaceutical Sciences
|
| Street address |
PO Box 6000
|
| City |
Binghamton |
| State/province |
NY |
| ZIP/Postal code |
13902 |
| Country |
USA |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA96267 |
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