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| Status |
Public on Jan 03, 2014 |
| Title |
Effects of NAFLD/NASH on hepatic gene expression. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To characterize gene expression changes in arachidonic acid metabolism pathway genes in the presense of non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) mice administered were administered an atherogenic diet for a period of four weeks. Administration of the atherogenic diet resulted in significant enrichment of the arachidonic acid metabolism pathway by gene set enrichment analysis (GSEA). The core enrichment subset of genes was down-regulated in mice administered the atherogenic diet and the majority of the genes that were down-regulated were cytochrome P450s.
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| Overall design |
A total of 4 wild-type mice were administered a standard diet (STD; control group) and 4 wild-type mice were administered a HFHC diet (HFHC).
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| Contributor(s) |
Schuck R, Lee C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 16, 2013 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Robert Schuck |
| E-mail(s) |
schuckrn@gmail.com
|
| Phone |
734230945
|
| Organization name |
UNC Chapel Hill
|
| Street address |
301 Pharmacy Lane
|
| City |
Chapel Hill |
| State/province |
North Carolina |
| ZIP/Postal code |
27599 |
| Country |
USA |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA231871 |
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