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| Status |
Public on Jul 12, 2006 |
| Title |
Spinal Cord Injury Murine Model |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Traumatic spinal cord injury (SCI) initiates a complex series of pathophysiological secondary responses that lead to tissue loss and functional deficits.This study represents a comprehensive database of temporal changes in gene expression that underlie the secondary injury response that occurs in a well-defined mouse model of contusion injury.
Keywords: Time-Series
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| Overall design |
Global changes in gene expression that contribute to secondary injury in a C57BL6 mouse model of contusion injury were evaluated using Affymetrix Mouse Genome 430 2.0 arrays.Mice were subjected to a moderate injury at the T8 spinal segment under isoflurane anesthesia.Sections of cord (0.4 cm in length) were analyzed from the site of impact and from the immediately adjacent rostral and caudal regions at 0.5, 4, 24, 72 h and 7 and 28 days after injury (n=3/per group), sham-injury (n=2 per group), or from naïve mice (n=2). Four mice were pooled for each individual n, for a total of 12 mice for each injury time point.
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| Contributor(s) |
Faden A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 12, 2006 |
| Last update date |
Oct 01, 2019 |
| Contact name |
Eric P Hoffman |
| E-mail(s) |
ericphoffman@gmail.com
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| Organization name |
Binghamton University - SUNY
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| Department |
Pharmaceutical Sciences
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| Street address |
PO Box 6000
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| City |
Binghamton |
| State/province |
NY |
| ZIP/Postal code |
13902 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (96)
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| Relations |
| BioProject |
PRJNA96419 |
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