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| Status |
Public on Nov 01, 2013 |
| Title |
Robust Differentiation of Islet Progenitors into Functional Insulin-secreting Cells by Suppression of Key Transcription Regulators |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene profiling revealed that differentiation was accompanied by suppression of a range of transcription regulator genes typical of islet progenitor cells. In order to understand molecular mechanisms of differentiation, transcriptome-wide gene expression analysis was performed on purified islet progenitors at days 0, 1 and 4 of differentiation together with adult islets as a control.
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| Overall design |
In order to understand molecular mechanisms of differentiation, transcriptome-wide gene expression analysis was performed on purified islet progenitors at days 0, 1 and 4 of differentiation together with adult islets as a control.
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| |
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| Contributor(s) |
Jiang FX, Nguyen Q, Mehta M, Morahan G |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 31, 2013 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Munish Mehta |
| E-mail(s) |
munish.mehta@uwa.edu.au
|
| Phone |
+61-8-92240397
|
| Organization name |
Harry Perkin Institute of Medical Reasearch
|
| Department |
Diabetes Research Unit
|
| Lab |
DRF
|
| Street address |
L6, Rear 50 Murray Street
|
| City |
Perth |
| State/province |
WA |
| ZIP/Postal code |
6000 |
| Country |
Australia |
| |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (13)
|
| GSM1255606 |
Embroynic Stem Cells, Replicate 1 |
| GSM1255607 |
Embroynic Stem Cells, Replicate 2 |
| GSM1255608 |
Islet Progenitors at Day 0 of differentiation, Replicate 1 |
| GSM1255609 |
Islet Progenitors at Day 0 of differentiation, Replicate 2 |
| GSM1255610 |
Islet Progenitors at Day 0 of differentiation, Replicate 3 |
| GSM1255611 |
Islet Progenitors at Day 0 of differentiation, Replicate 4 |
| GSM1255612 |
Islet Progenitors at Day 1 of differentiation, Replicate 1 |
| GSM1255613 |
Islet Progenitors at Day 1 of differentiation, Replicate 2 |
| GSM1255614 |
Islet Progenitors at Day 1 of differentiation, Replicate 3 |
| GSM1255615 |
Islet Progenitors at Day 4 of differentiation, Replicate 1 |
| GSM1255616 |
Islet Progenitors at Day 4 of differentiation, Replicate 2 |
| GSM1255617 |
Adult Islets, Replicate 1 |
| GSM1255618 |
Adult Islets, Replicate 2 |
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| Relations |
| BioProject |
PRJNA225884 |
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