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| Status |
Public on Dec 31, 2013 |
| Title |
Effects of anti-IL13RA mAbs on IL-4 or IL-13 signalling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
IL-4 and IL-13 are cytokines involved in type 2 immune responses involved in atopic asthma and other diseases. They have a partially overlapping set of cognate receptors whose roles are incompletely understood. Here we explore the effects of blocking one or both subunits of the IL-13 alpha receptor on the action of these cytokines on IMR-90 lung fibroblast cells.
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| Overall design |
IMR-90 lung fibroblast cells were cultured on matrigel and treated with various combinations of IL-4 (10 ng/ml), IL-13 (10ng/ml), 228 B/C (which blocks signaling from IL13RA1), and 11H4 (which blocks signaling from IL13RA1 and IL13RA2).
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| Contributor(s) |
Abbas AR, Arron JR, Chandriani S |
| Citation(s) |
24879793 |
| Submission date |
May 30, 2013 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Alex Abbas |
| E-mail(s) |
abbas@gene.com
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| Organization name |
Genentech, Inc.
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| Department |
Bioinformatics
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| Street address |
1 DNA Way
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| City |
South San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94080 |
| Country |
USA |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (35)
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| GSM1151583 |
IMR90, Mouse IgG, rep1 |
| GSM1151584 |
IMR90, Mouse IgG, rep2 |
| GSM1151585 |
IMR90, Mouse IgG, rep3 |
| GSM1151586 |
IMR90, IL13, rep1 |
| GSM1151587 |
IMR90, IL13, rep2 |
| GSM1151588 |
IMR90, IL13, rep3 |
| GSM1151589 |
IMR90, IL13 + 228B/C, rep1 |
| GSM1151590 |
IMR90, IL13 + 228B/C, rep2 |
| GSM1151591 |
IMR90, IL13 + 228B/C, rep3 |
| GSM1151592 |
IMR90, IL13 + 11H4, rep1 |
| GSM1151593 |
IMR90, IL13 + 11H4, rep2 |
| GSM1151594 |
IMR90, IL13 + 228B/C + 11H4, rep1 |
| GSM1151595 |
IMR90, IL13 + 228B/C + 11H4, rep2 |
| GSM1151596 |
IMR90, IL13 + 228B/C + 11H4, rep3 |
| GSM1151597 |
IMR90, IL13 + IL4 + Mouse IgG, rep1 |
| GSM1151598 |
IMR90, IL13 + IL4 + Mouse IgG, rep2 |
| GSM1151599 |
IMR90, IL13 + IL4 + Mouse IgG, rep3 |
| GSM1151600 |
IMR90, IL4 + Mouse IgG, rep1 |
| GSM1151601 |
IMR90, IL4 + Mouse IgG, rep2 |
| GSM1151602 |
IMR90, IL4 + Mouse IgG, rep3 |
| GSM1151603 |
IMR90, IL13 + IL4 + 228B/C, rep1 |
| GSM1151604 |
IMR90, IL13 + IL4 + 228B/C, rep2 |
| GSM1151605 |
IMR90, IL13 + IL4 + 228B/C, rep3 |
| GSM1151606 |
IMR90, IL13 + IL4 + 11H4, rep1 |
| GSM1151607 |
IMR90, IL13 + IL4 + 11H4, rep2 |
| GSM1151608 |
IMR90, IL13 + IL4 + 11H4, rep3 |
| GSM1151609 |
IMR90, IL13 + IL4 + 228B/C + 11H4, rep1 |
| GSM1151610 |
IMR90, IL13 + IL4 + 228B/C + 11H4, rep2 |
| GSM1151611 |
IMR90, IL13 + IL4 + 228B/C + 11H4, rep3 |
| GSM1151612 |
IMR90, IL13 + Mouse IgG, rep1 |
| GSM1151613 |
IMR90, IL13 + Mouse IgG, rep2 |
| GSM1151614 |
IMR90, IL13 + Mouse IgG, rep3 |
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| Relations |
| BioProject |
PRJNA205955 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE47527_RAW.tar |
153.3 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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