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| Status |
Public on Jun 09, 2013 |
| Title |
Targeting BCL-2 with the BH3 mimetic ABT-199 in ER-positive breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
A bank of human breast tumor xenografts was established by serial passage of primary breast tumor fragments in the cleared mammary fat pads of immuno-compromised NOD-SCID-IL2Rgammac-/- mice. The expression profiles from four different tumors (23T, 315T, 50T and 838T) were classified using diagonal discriminant analysis. The training data set consisted of 1992 samples from Curtis et al. (2012, PMID: 22522925); class labels were based on tumor subtype information provided (Basal-like, Luminal A, Luminal B, HER2-enriched and Normal breast-like).
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| Overall design |
Total RNA obtained from xenograft tumors from different patients have been profiled on the Illumina HT-12 BeadChip platform.
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| Contributor(s) |
Ritchie ME |
| Citation(s) |
23845444 |
| Submission date |
May 24, 2013 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Matthew Ritchie |
| E-mail(s) |
mritchie@wehi.edu.au
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| Organization name |
The Walter and Eliza Hall Institute of Medical Research
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| Department |
Epigenetics and Development Division
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| Street address |
1G Royal Parade
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| City |
Parkville |
| State/province |
Victoria |
| ZIP/Postal code |
3052 |
| Country |
Australia |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA205300 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE47369_RAW.tar |
26.2 Mb |
(http)(custom) |
TAR |
| GSE47369_non-normalized.txt.gz |
2.0 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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