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| Status |
Public on Jul 12, 2013 |
| Title |
Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We identified eighty two skin transcripts significantly correlated with the severity of interstitial lung disease (ILD) in systemic sclerosis.
These genes separated patients with more sever ILD in unsupervised hierarchical clustering. Pathway analysis revealed pathways involved in extravasation and adhesion of inflammatory cells to endothelium.
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| Overall design |
Skin biopsy samples from 59 patients enrolled in the GENISOS cohort or an open label imatinib study were examined by global gene expression studies.
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| |
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| Contributor(s) |
Assassi S, Wu M, Tan FK, Chang JT, Graham TA, Furst DE, Khanna D, Charles J, Ferguson EC, Feghali-Bostwick C, Mayes MD |
| Citation(s) |
23897225 |
| Submission date |
May 21, 2013 |
| Last update date |
Jun 22, 2021 |
| Contact name |
Jeffrey Chang |
| E-mail(s) |
jeffrey.t.chang@uth.tmc.edu
|
| Organization name |
University of Texas
|
| Street address |
6431 Fannin St
|
| City |
Houston |
| ZIP/Postal code |
77019 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (59)
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| Relations |
| BioProject |
PRJNA204810 |
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