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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 30, 2006 |
| Title |
Expression data from myogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
During muscle differentiation, myogenesis sepcific genes are differentially regulated, including Lamins that function at least in maintenance of nuclear architecture and regulation of gene expression.
We used microarrays to detail the global changes of gene expression in lamins and nuclear envelope assoicated proteins during myogenesis.
Keywords: comparative, myogenesis
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| Overall design |
C2C12 were cultured either in 20% serum (undifferentiated) or in 2% horse serum (differentiated). Differentiated C2C12 cells were harvested on day 6 after induction of myogenesis in low serum. Affymetirx microarray raw data were further processed by GCRMA to globally normalized signal values and then subjected to analysis of Bayesian regularized t-test. Gene expression, that has a p-value less than 0.05 in the t-test and has more than 1.5 fold change, was considered siginificant.
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| Contributor(s) |
Chen IB, Gerace L |
| Citation(s) |
17062158, 19720741 |
| Submission date |
Apr 20, 2006 |
| Last update date |
Aug 28, 2019 |
| Contact name |
Ihsiung Brandon Chen |
| E-mail(s) |
IBCHEN@YAHOO.COM
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| Organization name |
The Scripps Research Institute
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| Department |
Cell Biology
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| Lab |
Larry Gerace
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| Street address |
10550 N. Torrey Pines Rd.
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| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| GSM106142 |
myoblast undifferentiated C2C12, biological rep1 |
| GSM106143 |
myoblast undifferentiated C2C12, biological rep2 |
| GSM106144 |
myoblast undifferentiated C2C12, biological rep3 |
| GSM106145 |
myotubes, differentiated C2C12, biological rep1 |
| GSM106146 |
myotubes, differentiated C2C12, biological rep2 |
| GSM106147 |
myotubes, differentiated C2C12, biological rep3 |
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| Relations |
| BioProject |
PRJNA96741 |
| Supplementary data files not provided |
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