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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 13, 2013 |
| Title |
IQGAP2 knockout model of hepatocellular carcinoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Whole body knockout mice lacking IQ-motif containing GTPase-activating protein 2 (IQGAP2) develop spontaneous hepatocellular carcinoma (HCC) at the age of 12 months and older (Schmidt et al., 2008). Hepatic transcript expression profiles were obtained for IQGAP2 knockout and wild-type control mice of two age groups, 6- and 24-month-old. Liver samples from 24-month-old IQGAP2 knockout mice were HCC tumors, livers from all other groups were tumor-free. Results provide insights into the potential role of IQGAP2 as a liver-specific tumor suppressor.
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| Overall design |
Transcript profiles of four groups of mouse livers (N = 3 in each group) were compared using Affymetrix GeneChip® Mouse Genome 430 2.0 Array. The groups included livers from 6- and 24-month-old wild-type (WT) mice and 6- and 24-month-old (KO) Iqgap2-/- mice.
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| Contributor(s) |
Gnatenko DV, Xu X, Zhu W, Schmidt VA |
| Citation(s) |
23951254 |
| Submission date |
May 05, 2013 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Dmitri V GNATENKO |
| E-mail(s) |
dimitri.gnatenko@stonybrook.edu
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| Phone |
631-444-1264
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| Organization name |
Stony Brook University
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| Department |
Medicine
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| Street address |
T15/053 HSC SUNY
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| City |
Stony Brook |
| State/province |
NY |
| ZIP/Postal code |
11794 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (12)
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| GSM1133576 |
Knockout mouse at 6 months, biological replicate 1 |
| GSM1133577 |
Knockout mouse at 6 months, biological replicate 2 |
| GSM1133578 |
Knockout mouse at 6 months, biological replicate 3 |
| GSM1133579 |
Knockout mouse at 24 months, biological replicate 1 |
| GSM1133580 |
Knockout mouse at 24 months, biological replicate 2 |
| GSM1133581 |
Knockout mouse at 24 months, biological replicate 3 |
| GSM1133582 |
Wild-type mouse at 6 months, biological replicate 1 |
| GSM1133583 |
Wild-type mouse at 6 months, biological replicate 2 |
| GSM1133584 |
Wild-type mouse at 6 months, biological replicate 3 |
| GSM1133585 |
Wild-type mouse at 24 months, biological replicate 1 |
| GSM1133586 |
Wild-type mouse at 24 months, biological replicate 2 |
| GSM1133587 |
Wild-type mouse at 24 months, biological replicate 3 |
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| Relations |
| BioProject |
PRJNA201382 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE46646_RAW.tar |
44.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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