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| Status |
Public on Jul 01, 2006 |
| Title |
Telomere dysfunction |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We used microarrays to analyze the prevalence of signalling induced by acute telomere dysfunction (as induced by TRF2DBDM expression = Dataset 1) and in TERC- compared to TERC+ HCC (Dataset 2).
Keywords: acute telomere dysfunction, hepatocellular cancer
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| |
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| Overall design |
Presented are gene expression data from:
Dataset 1: Mouse liver 48h after i.v. infection of p53-/- mice with Ad TRF2DBDM compared to Ad GFP (2x10^10 PFU) (GSM103546, GSM103547) and
Dataset 2: p53-/- heptaocellular carcinoma (HCC) from mTERC+ HBs (GSM103548, GSM103549, GSM103553) compared to mTERC-, HBs (GSM103550, GSM103551, GSM103552) transgenic mice.
All mice were in a C57BL/6J background.
Dataset 1: Liver RNA was extracted 48h after adenoviral infection (n=3 mice/group), samples were pooled for hybridization on Affymetrix microarrays.
Dataset 2: RNA was extracted from HCC of 12-15month old mTERC+ and mTERC- mice (n=3 mice/group). Individual tumors were hybridized on Affymetrix microarrays.
Differentially expressed gene clusters were identified using Array Assist 4.0 (Stratagene).
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| Contributor(s) |
Lechel A, Rudolph KL, Geffers R |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 06, 2006 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Robert Geffers |
| E-mail(s) |
robert.geffers@helmholtz-hzi.de
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| Phone |
+49 531-6181-3058
|
| Organization name |
HCI - Helmholtz Centre for Infection Research
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| Department |
Dep. Molecular Bacteriology
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| Lab |
Genome Analytics
|
| Street address |
Inhoffenstr. 7
|
| City |
Braunschweig |
| ZIP/Postal code |
38124 |
| Country |
Germany |
| |
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| Platforms (2) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA95523 |
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