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| Status |
Public on Apr 20, 2015 |
| Title |
Brain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Social stress mouse models were used to simulate human post-traumatic stress disorder (PTSD). C57B/6 mice exposed to SJL aggressor mice exhibited behaviors accepted as PTSD-in-mouse phenotype: 'frozen' motion, aggressor’s barrier avoidance, startled jumping, and retarded locomotion. Transcripts in hippocampus, amygdala, medial prefrontal cortex, ventral striatum (nucleus acumbens), septal region, corpus striatum, hemi-brain, blood, spleen and heart of stressed and control C57B/6 mice were analyzed using Agilent’s mouse genome-wide arrays.
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| Overall design |
C57B6 mice were exposed to SJL aggressor mice for periods of 5 days and 10days (6 hours each day) to induce anxiety/stress which parallels to PTSD in human
Organs, blood and brain regions were collected after 24 hours and 1.5 week of post 5 days social defeat period; and 24 hour and 6 weeks post 10 days social stress period.
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| Contributor(s) |
Muhie S, Hammamieh R, Jett M |
| Citation(s) |
25888136, 28534873 |
| Submission date |
Mar 12, 2013 |
| Last update date |
Aug 31, 2017 |
| Contact name |
seid muhie |
| E-mail(s) |
yimersm@gmail.com
|
| Organization name |
USACEHR
|
| Department |
Systems Biology Enterprise
|
| Street address |
568 Doughten Dr
|
| City |
Fort Detrick |
| State/province |
MD |
| ZIP/Postal code |
21702 |
| Country |
USA |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (230)
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| This SubSeries is part of SuperSeries: |
| GSE68077 |
Transcriptome characterization of social stressed C57B6 mice exhibiting PTSD like features |
|
| Relations |
| BioProject |
PRJNA192884 |
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