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| Status |
Public on Jun 08, 2003 |
| Title |
Leprosy lesion gene expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.
Keywords: other
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| Citation(s) |
12970564 |
| Submission date |
Jun 03, 2003 |
| Last update date |
Dec 13, 2018 |
| Contact name |
Joshua Bleharski |
| E-mail(s) |
jrbleharski@yahoo.com
|
| Phone |
310-231-3530
|
| Organization name |
UCLA
|
| Street address |
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (1) |
| GPL8300 |
[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA85029 |
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