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Status |
Public on Feb 11, 2013 |
Title |
TCR affinity-dependent functional inhibition via PD-1 and SHP-1 phosphatase |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
|
Summary |
To investigate gene expression changes associated with stimulation of TCRs of different affinity, primary CD8 T cells were transduced with sequence optimized TCRs of various affinities and stimulated for 6h.
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Overall design |
Gene expression was measured at baseline (0h) and after 6h after stimulation with low dose NY-ESO-1 multimer
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Contributor(s) |
Rufer N, Hebeisen M, Baitsch L |
Citation(s) |
23391724 |
Submission date |
Dec 14, 2012 |
Last update date |
Jan 23, 2019 |
Contact name |
Lukas Baitsch |
E-mail(s) |
lukas_baitsch@dfci.harvard.edu
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Organization name |
Dana Farber Cancer Institute
|
Department |
Cancer Biology
|
Lab |
Jean Zhao
|
Street address |
450 Brookline Avenue
|
City |
Boston |
State/province |
MA |
ZIP/Postal code |
02215 |
Country |
USA |
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Platforms (1) |
GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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Samples (16)
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Relations |
BioProject |
PRJNA183876 |