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Series GSE40785

Query DataSets for GSE40785

Status

Public on Jun 16, 2015

Title

Characterization of novel ovarian tumor cell lines that retain the phenotype of primary tumors [Illumina]

Organism

Homo sapiens

Experiment type

Expression profiling by array

Summary

The inability to establish stable cell lines from the vast majority of human tumors has limited the use of in vitro models to study human cancer. Currently available tumor cell lines fail to represent the biological diversity of human tumors. We have developed a cell culture medium that enabled us to routinely establish cell lines from diverse subtypes of ovarian tumors. Importantly, the twenty-five ovarian tumor cell lines described here retain the genomic landscape, histopathology, and molecular features of the original tumors. Furthermore, the molecular profile and drug response of these cell lines correlated with distinct groups of primary tumors with different outcomes. Thus, tumor cell lines derived using this methodology represent a significantly improved new platform to study human tumor biology and treatment.

Overall design

Total RNA was obtained from untreated ovarian cancer cell lines and clustering analysis was performed.

The 'Median-Cent_5147_probes.txt' is a list of the 5147 gene probes that has at least 2-fold difference relative to median value across cell lines in at least 4 samples. These are the probes that were used for hierarchial clustering analysis.

The 'Combined_and_GSE9891.txt' is a combination of gene probes from this study of ovarian cell lines and of human ovarian cancer cell lines (GSE9891[GPL570]: Expression profile of 285 ovarian tumour samples). Only the 3832 overlapping gene probes between the this study and the GSE9891[GPL570] study are listed. The 3832 gene probes listed have at least 2-fold difference relative to median value across samples in at least 4 samples.

Contributor(s)

Ince TA, Krohn M, Liu W, Sousa AD

Citation missing

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Submission date

Sep 11, 2012

Last update date

Aug 13, 2018

Contact name

Tan A Ince

E-mail(s)

Tince@med.miami.edu

Phone

305-243-1782

Organization name

University of Miami - Miller School of Medicine

Department

Sylvester Cancer Center

Lab

Dr. Ince Lab - TCC

Street address

1501 NW 10th Avenue, Rm 926

City

Miami

State/province

ZIP/Postal code

33136

Country

USA

Platforms (1)

GPL10558

Illumina HumanHT-12 V4.0 expression beadchip

Samples (37)

More...

GSM1001395	OCI-M1p
GSM1001396	OCI-C5x
GSM1001397	OCI-C4p

This SubSeries is part of SuperSeries:

GSE40788

Characterization of novel ovarian tumor cell lines that retain the phenotype of primary tumors

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BioProject

Download family	Format
SOFT formatted family file(s)	SOFT
MINiML formatted family file(s)	MINiML
Series Matrix File(s)	TXT

Supplementary file	Size	Download	File type/resource
GSE40785_Agoston_Median-Cent_5147_probes.txt.gz	528.6 Kb	(ftp)(http)	TXT
GSE40785_Combined_Agoston_and_GSE9891.txt.gz	3.1 Mb	(ftp)(http)	TXT
GSE40785_RAW.tar	26.2 Mb	(http)(custom)	TAR
GSE40785_non_normalized.txt.gz	12.4 Mb	(ftp)(http)	TXT
Processed data included within Sample table
Processed data are available on Series record