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| Status |
Public on Sep 20, 2013 |
| Title |
Expression data from peripheral blood - blood draws at Pre and Post time points of Allergen inhalation challenge (ER and DR) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To determine differential gene expression in peripheral blood of asthmatic individuals undergoing allergen inhalation challenge between early responders (ERs) and dual responders (DRs) following allergen inhalation challenge
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| Overall design |
Blood was collected immediately prior to, and two hours after challenge
The change in gene expression (post expression minus pre expression) in ERs was compared with the change in gene expression in DRs using age and sex as covariates
Preprocessing and probeset filtering were applied to the entire dataset (28 CEL files) using the Factor Analysis for Robust MicroArray Summarization (farms) package in R
The Linear Models for MicroArrays (limma) package was used to determine differential gene expression using a Benjamini Hochberg FDR of 10%.
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| Contributor(s) |
Singh A, Yamamoto M, Kam SH, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Boulet L, Wojewodka G, Kanagaratham C, De Sanctis JB, Radzioch D, Tebbutt SJ |
| Citation(s) |
23844124 |
| Submission date |
Aug 20, 2012 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Scott Tebbutt |
| E-mail(s) |
scott.tebbutt@hli.ubc.ca
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| Organization name |
University of British Columbia
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| Department |
Medicine
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| Lab |
James Hogg Research Centre
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| Street address |
Room 166, 1081 Burrard Street
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| City |
Vancouver |
| State/province |
BC |
| ZIP/Postal code |
V6Z 1Y6 |
| Country |
Canada |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (28)
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| GSM989156 |
Subject LST019, biological rep1 |
| GSM989157 |
Subject LST012, biological rep1 |
| GSM989158 |
Subject LST021, biological rep1 |
| GSM989159 |
Subject LST026, biological rep1 |
| GSM989160 |
Subject STS007, biological rep1 |
| GSM989161 |
Subject LST013, biological rep1 |
| GSM989162 |
Subject LST017, biological rep1 |
| GSM989163 |
Subject LST018, biological rep1 |
| GSM989164 |
Subject LST020, biological rep1 |
| GSM989165 |
Subject LST022, biological rep1 |
| GSM989166 |
Subject STS009, biological rep1 |
| GSM989167 |
Subject LST003, biological rep2 |
| GSM989168 |
Subject LST014, biological rep2 |
| GSM989169 |
Subject LST016, biological rep2 |
| GSM989170 |
Subject LST019, biological rep2 |
| GSM989171 |
Subject LST012, biological rep2 |
| GSM989172 |
Subject LST021, biological rep2 |
| GSM989173 |
Subject LST026, biological rep2 |
| GSM989174 |
Subject STS007, biological rep2 |
| GSM989175 |
Subject LST013, biological rep2 |
| GSM989176 |
Subject LST017, biological rep2 |
| GSM989177 |
Subject LST018, biological rep2 |
| GSM989178 |
Subject LST020, biological rep2 |
| GSM989179 |
Subject LST022, biological rep2 |
| GSM989180 |
Subject STS009, biological rep2 |
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| Relations |
| BioProject |
PRJNA173271 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE40240_RAW.tar |
106.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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