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| Status |
Public on Apr 22, 2013 |
| Title |
Genome-wide expression profiling analysis of a SMC6 mutant mouse model |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The function of the SMC5-6 complex is less clear, but it has an important role in a variety of different DNA repair processes and in resolving recombination structures. Interestingly mutation at a highly conserved residue (Ser994) in the ATP hydrolysis motif in the SMC6 C-terminal domain, resulted in mice with a mild phenotype.
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| Overall design |
Total RNA obtained from homozygote 4 male mutant mice was compared to 2-4 wild type or 2 heterozygote controls.
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| |
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| Contributor(s) |
Beckers J, Horsch M |
| Citation(s) |
23518413 |
| Submission date |
Jun 15, 2012 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Martin Irmler |
| Organization name |
Helmholtz Zentrum München GmbH
|
| Department |
Institute of Experimental Genetics
|
| Lab |
Gene Regulation & Epigenetics
|
| Street address |
Ingolstaedter Landstrasse 1
|
| City |
Neuherberg |
| State/province |
Bayern |
| ZIP/Postal code |
85764 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (24)
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| Relations |
| BioProject |
PRJNA168573 |
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