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| Status |
Public on Apr 17, 2013 |
| Title |
Expression data from post mortem Alzheimer's disease brains |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To identify molecular pathological alterations in AD brains, we performed interspecies comparative microarray analyses using RNAs prepared from postmortem human brain tissues donated for the Hisayama study and hippocampal RNAs from the triple-transgenic mouse model of AD (3xTg-AD)
Three-way ANOVA of microarray data from frontal cortex, temporal cortex and hippocampus with presence/absence of AD and vascular dementia, and sex, as factors revealed that the gene expression profile is most significantly altered in the hippocampi of AD brains. Comparative analyses of the brains of AD patients and a mouse model of AD showed that genes involved in non-insulin dependent DM and obesity were significantly altered in both, as were genes related to psychiatric disorders and Alzheimer’s disease.
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| Overall design |
We prepared RNA samples from the gray matter of frontal and temporal cortices and hippocampi derived from 88 postmortem brains, among which 26 cases were pathologically diagnosed as having AD or an AD-like disorder. High-quality RNA (RIN≧6.9) samples were subjected to microarray analysis using the Affymetrix Human Gene 1.0 ST platform, and only those results that passed examinations for quality assurance and quality control of the Human Gene 1.0 ST arrays were retrieved. In total, we obtained gene expression profiles from the following samples: 33 frontal cortex samples, among which 15 were from AD patients; 29 temporal cortex samples, among which 10 were from AD patients; 18 hippocampus samples, among which 8 were from AD patients
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| Contributor(s) |
Nakabeppu Y, Hokama M, Abolhassani N |
| Citation(s) |
23595620 |
| Submission date |
Apr 02, 2012 |
| Last update date |
Sep 06, 2020 |
| Contact name |
Yusaku Nakabeppu |
| E-mail(s) |
yusaku@bioreg.kyushu-u.ac.jp
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| Phone |
81-92-642-6800
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| Organization name |
Medical Institute of Bioregulation, Kyushu University
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| Department |
Department of Immunobiology and Neuroscience
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| Lab |
Division of Neurofunctional Genomics
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| Street address |
3-1-1 Maidashi Higashi-ku
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| City |
Fukuoka |
| State/province |
Fukuoka |
| ZIP/Postal code |
812-8582 |
| Country |
Japan |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (80)
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| GSM907795 |
AD_FC, biological rep4 |
| GSM907796 |
AD_FC, biological rep5 |
| GSM907797 |
AD_FC, biological rep6 |
| GSM907798 |
AD_FC, biological rep7 |
| GSM907799 |
AD_FC, biological rep8 |
| GSM907800 |
AD_FC, biological rep9 |
| GSM907801 |
AD_FC, biological rep10 |
| GSM907802 |
AD_FC, biological rep11 |
| GSM907803 |
AD_FC, biological rep12 |
| GSM907804 |
AD_FC, biological rep13 |
| GSM907805 |
AD_FC, biological rep14 |
| GSM907806 |
AD_FC, biological rep15 |
| GSM907807 |
non-AD_FC, biological rep1 |
| GSM907808 |
non-AD_FC, biological rep2 |
| GSM907809 |
non-AD_FC, biological rep3 |
| GSM907810 |
non-AD_FC, biological rep4 |
| GSM907811 |
non-AD_FC, biological rep5 |
| GSM907812 |
non-AD_FC, biological rep6 |
| GSM907813 |
non-AD_FC, biological rep7 |
| GSM907814 |
non-AD_FC, biological rep8 |
| GSM907815 |
non-AD_FC, biological rep9 |
| GSM907816 |
non-AD_FC, biological rep10 |
| GSM907817 |
non-AD_FC, biological rep11 |
| GSM907818 |
non-AD_FC, biological rep12 |
| GSM907819 |
non-AD_FC, biological rep13 |
| GSM907820 |
non-AD_FC, biological rep14 |
| GSM907821 |
non-AD_FC, biological rep15 |
| GSM907822 |
non-AD_FC, biological rep16 |
| GSM907823 |
non-AD_FC, biological rep17 |
| GSM907824 |
non-AD_FC, biological rep18 |
| GSM907825 |
AD_TC, biological rep1 |
| GSM907826 |
AD_TC, biological rep2 |
| GSM907827 |
AD_TC, biological rep3 |
| GSM907828 |
AD_TC, biological rep4 |
| GSM907829 |
AD_TC, biological rep5 |
| GSM907830 |
AD_TC, biological rep6 |
| GSM907831 |
AD_TC, biological rep7 |
| GSM907832 |
AD_TC, biological rep8 |
| GSM907833 |
AD_TC, biological rep9 |
| GSM907834 |
AD_TC, biological rep10 |
| GSM907835 |
non-AD_TC, biological rep1 |
| GSM907836 |
non-AD_TC, biological rep2 |
| GSM907837 |
non-AD_TC, biological rep3 |
| GSM907838 |
non-AD_TC, biological rep4 |
| GSM907839 |
non-AD_TC, biological rep5 |
| GSM907840 |
non-AD_TC, biological rep6 |
| GSM907841 |
non-AD_TC, biological rep7 |
| GSM907842 |
non-AD_TC, biological rep8 |
| GSM907843 |
non-AD_TC, biological rep9 |
| GSM907844 |
non-AD_TC, biological rep10 |
| GSM907845 |
non-AD_TC, biological rep11 |
| GSM907846 |
non-AD_TC, biological rep12 |
| GSM907847 |
non-AD_TC, biological rep13 |
| GSM907848 |
non-AD_TC, biological rep14 |
| GSM907849 |
non-AD_TC, biological rep15 |
| GSM907850 |
non-AD_TC, biological rep16 |
| GSM907851 |
non-AD_TC, biological rep17 |
| GSM907852 |
non-AD_TC, biological rep18 |
| GSM907853 |
non-AD_TC, biological rep19 |
| GSM907854 |
AD_HI, biological rep1 |
| GSM907855 |
AD_HI, biological rep2 |
| GSM907856 |
AD_HI, biological rep3 |
| GSM907857 |
AD_HI, biological rep4 |
| GSM907858 |
AD_HI, biological rep5 |
| GSM907859 |
AD_HI, biological rep6 |
| GSM907860 |
AD_HI, biological rep7 |
| GSM907861 |
non-AD_HI, biological rep1 |
| GSM907862 |
non-AD_HI, biological rep2 |
| GSM907863 |
non-AD_HI, biological rep3 |
| GSM907864 |
non-AD_HI, biological rep4 |
| GSM907865 |
non-AD_HI, biological rep5 |
| GSM907866 |
non-AD_HI, biological rep6 |
| GSM907867 |
non-AD_HI, biological rep7 |
| GSM907868 |
non-AD_HI, biological rep8 |
| GSM907869 |
non-AD_HI, biological rep9 |
| GSM907870 |
non-AD_HI, biological rep10 |
| GSM4764672 |
AD_HI, biological rep8 |
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| Relations |
| BioProject |
PRJNA157435 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE36980_RAW.tar |
364.1 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data provided as supplementary file |
| Processed data included within Sample table |
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