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| Status |
Public on Jun 01, 2013 |
| Title |
Protein Tyrosine Phosphatase UBASH3B is Overexpressed in Triple-Negative Breast Cancer and Promotes Invasion and Metastasis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Efforts to improve the clinical outcome of highly aggressive triple-negative breast cancer (TNBC) have been hindered by the lack of effective targeted therapies. Thus, it is important to identify the specific gene targets/pathways driving the invasive phenotype to develop more effective therapeutics. Here we show that ubiquitin-associated and SH3 domain-containing B (UBASH3B), a protein tyrosine phosphatase, is overexpressed in TNBC, where it supports malignant growth, invasion, and metastasis largely through modulating epidermal growth factor receptor (EGFR). We also show that UBASH3B is a functional target of anti-invasive microRNA200a (miR200a) that is down-regulated in TNBC. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity, which targets CBL ubiquitin ligase for dephosphorylation and inactivation, leading to EGFR up-regulation. Thus, UBASH3B may function as a crucial node in bridging multiple invasion-promoting pathways, thereby providing a potential therapeutic target for TNBC.
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| Overall design |
Breast cancer tissues and breast cancer cell lines
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| Contributor(s) |
Lee ST, Feng M, Wei Y, Wong CH, Qiao Y, Guan P, Li Z, Wang J, Jiang X, Karuturi KM, Tan EY, Hoon D, Kang Y, Yu Q, Li J, Huynh K |
| Citation(s) |
23784775 |
| Submission date |
Mar 21, 2012 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Peiyong Guan |
| E-mail(s) |
p.g@u.duke.nus.edu
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| Organization name |
Genome Institute of Singapore
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| Street address |
60 Biopolis Street, Genome, #02-01
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| City |
Singapore |
| ZIP/Postal code |
138672 |
| Country |
Singapore |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (101)
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| Relations |
| BioProject |
PRJNA153615 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE36693_RAW.tar |
26.2 Mb |
(http)(custom) |
TAR |
| GSE36693_non-normalized.txt.gz |
17.0 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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