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| Status |
Public on Jan 02, 2013 |
| Title |
NOD2 transmissible microbiota predispose WT mice to inflammation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Instability in the composition of gut bacterial communities, referred as dysbiosis, has been associated with important human intestinal disorders such as Crohn’s disease and colorectal cancer. Our data showed that Nod2-mediated risk of intestinal inflammation in colitis model is communicable to WT mice by cohousing. Here, we investigated if Nod2-deficient mice microbiota is able to change transcript profiles in Nod2-immunocompetent mice (C57Bl6/J mice) independently of colitis.
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| Overall design |
Analysis used RNA extracted from colonic mucosa of C57Bl/6J mice co-housed with Nod2-deficient mice and C57Bl/6J mice alone. Direct comparisons of 4 biologicals replicates of C57Bl/6J mice cohoused with Nod2-deficient mice vs C57Bl/6J mice were performed.
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| Contributor(s) |
Couturier A, Chamaillard M, Hot D, Huot L |
| Citation(s) |
23281400, 35917251 |
| Submission date |
Mar 13, 2012 |
| Last update date |
Aug 11, 2022 |
| Contact name |
David Hot |
| E-mail(s) |
david.hot@pasteur-lille.fr
|
| Organization name |
Institut Pasteur de Lille
|
| Department |
Center for Infection and Immunity of Lille
|
| Lab |
Transcriptomics and Applied Genomics
|
| Street address |
1 rue du professeur Calmette
|
| City |
Lille |
| ZIP/Postal code |
59000 |
| Country |
France |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
|
| Samples (4)
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| GSM894491 |
B6 co-housed with Nod2 repl1 vs B6 repl1 |
| GSM894492 |
B6 co-housed with Nod2 repl1 vs B6 repl2 |
| GSM894493 |
B6 co-housed with Nod2 repl1 vs B6 repl3 |
| GSM894494 |
B6 co-housed with Nod2 repl1 vs B6 repl4 |
|
| Relations |
| BioProject |
PRJNA153517 |
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