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| Status |
Public on Oct 29, 2012 |
| Title |
Expression Data from hypothalamus of IL-6 deficient mice and their wild-type littermates following intraperitoneal LPS challenge |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
IL-6 has been described to be a critical cytokine in mediating the febrile response because neither IL-6 knockout mice injected with peripheral lipopolysaccharide (LPS) or IL-1β, nor animals treated with IL-6 antiserum develop fever. However, the fever response is developed in IL-6 KO mice following intracerebroventricular administration of Prostaglandin E2 which is the principal mediator of the febrile response.
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| Overall design |
We performed a genome-wide microarray expression comparison between LPS-treated WT and IL-6 KO mice to evaluate if there were any differentially expressed genes in mice devoid of IL-6 that can explain the absence of fever response.
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| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 22, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Namik Hamzic |
| E-mail(s) |
namik.hamzic@liu.se
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| Organization name |
University of Health
|
| Department |
Institution for clinical and experimental medicin
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| Lab |
Cell biology
|
| Street address |
Linköpings Universitet
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| City |
Linköping |
| ZIP/Postal code |
58185 |
| Country |
Sweden |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA150323 |
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