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| Status |
Public on Nov 05, 2011 |
| Title |
Genome-wide analysis of gene transcription in myocardium of mice transgenically expressing human cardiolipin synthase 1 (hCLS1) in cardiac tissue |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of the transcriptome of cardiac tissue from mice transgenically expressing human cardiolipin synthesis. The hypothesis tested was that cardiac specific transgenic expression of cardiolipin synthase alters myocardial lipidomic flux resulting in compensatory metabolic gene transcriptional changes that will attenuate pathological environmental and dietary insults on bioenergetics.
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| |
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| Overall design |
Total RNA obtained from cardiac tissue from transgenic cardiac specific expressing human cardiolipin synthase 1 (hCLS1) mouse model at 4 months of age compared to wildtype littermates
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| |
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| Contributor(s) |
Kiebish MA, Gross RW, Han X |
| Citation(s) |
22584571 |
| Submission date |
Nov 03, 2011 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Michael Andrew Kiebish |
| E-mail(s) |
kiebish@wustl.edu
|
| Phone |
314-362-2229
|
| Fax |
314-362-1402
|
| Organization name |
Washington University School of Medicine
|
| Department |
Internal Medicine
|
| Lab |
Richard W. Gross
|
| Street address |
660 South Euclid Avenue, Campus Box 8020
|
| City |
Saint Louis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (8)
|
| GSM827096 |
Heart 4 month old WT rep1 (mouse 5976) |
| GSM827097 |
Heart 4 month old WT rep2 (mouse 5977) |
| GSM827098 |
Heart 4 month old WT rep3 (mouse 5966) |
| GSM827099 |
Heart 4 month old WT rep4 (mouse 5967) |
| GSM827100 |
Heart 4 month old CLS rep1 (mouse 5978) |
| GSM827101 |
Heart 4 month old CLS rep2 (mouse 5968) |
| GSM827102 |
Heart 4 month old CLS rep3 (mouse 5979) |
| GSM827103 |
Heart 4 month old CLS rep4 (mouse 5969) |
|
| Relations |
| BioProject |
PRJNA148711 |
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