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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 24, 2012 |
| Title |
Gene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-cre;KrasLSL-G12D;IKK2/beta F/F mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Constitutive Kras and NF-kB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). Here, we report that pancreas-targeted IKK2/beta inactivation inhibited NF-kB activation and completely suppressed PDAC development. Our findings demonstrated that NF-kB is required for development of pancreatic ductal adenocarcinoma that was initiated by Kras activation.
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| Overall design |
Pancreatic tissue from 4 groups of mice were used in this project: (1) the pancreas normal appearance of Pdx1-cre;KrasLSL-G12D;IKK2/beta mice, (2) the normal pancreas of Pdx1-cre;KrasLSL-G12D mice, (3) the pancreatic lesion of pancreatic intraepithelial neoplasia (PanIN) of Pdx1-cre;KrasLSL-G12D mice, and (4) the pancreatic lesion of PDAC of Pdx1-cre;KrasLSL-G12D mice. Each group included three mice. RNA samples from mouse pancreas were hybridized on GeneChip Mouse Gene 1.0 ST arrays (Affymetrix). Group (1) and group (2) were compared, and group (2), group (3) and group (4) were compared.
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| Contributor(s) |
Ling J, Chiao PJ |
| Citation(s) |
22264792 |
| Submission date |
Oct 28, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Paul J Chiao |
| E-mail(s) |
pjchiao@mdanderson.org
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| Phone |
(713) 794-1030
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| Fax |
(713) 794-4830
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| Organization name |
The University of Texas M. D. Anderson Cancer Center
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| Department |
Department of Molecular and Cellular Oncology
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| Street address |
1515 Holcombe Blvd
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| City |
Houston |
| State/province |
Texas |
| ZIP/Postal code |
770300 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| GSM829911 |
Normal pancreas, Kras-Pdx1-cre, biological rep1 |
| GSM829912 |
Normal pancreas, Kras-Pdx1-cre, biological rep2 |
| GSM829913 |
Normal pancreas, Kras-Pdx1-cre, biological rep3 |
| GSM829914 |
PanIN, Kras-Pdx1-cre, biological rep1 |
| GSM829915 |
PanIN, Kras-Pdx1-cre, biological rep2 |
| GSM829916 |
PanIN, Kras-Pdx1-cre, biological rep3 |
| GSM829917 |
PDAC, Kras-Pdx1-cre, biological rep1 |
| GSM829918 |
PDAC, Kras-Pdx1-cre, biological rep2 |
| GSM829919 |
PDAC, Kras-Pdx1-cre, biological rep3 |
| GSM829920 |
pancreas normal, Kras-Pdx1-cre-IKK2, biological rep1 |
| GSM829921 |
pancreas normal, Kras-Pdx1-cre-IKK2, biological rep2 |
| GSM829922 |
pancreas normal, Kras-Pdx1-cre-IKK2, biological rep3 |
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| This SubSeries is part of SuperSeries: |
| GSE33323 |
Kras-induced ikk2/nf-kappaB activation by IL-1 alpha and p62 freedforward loops is required for development of pancreatic ductal adenocarcinoma |
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| Relations |
| BioProject |
PRJNA156643 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE33322_RAW.tar |
40.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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