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| Status |
Public on Dec 31, 2013 |
| Title |
Gene expression profile of YAP1, TEAD1 and KLF5 in hepatocellular carcinoma cell line (SK-Hep1) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Hippo signaling pathway is pivotally involved in human cancer. Among the Hippo components, YAP1 is highly active while function of MST1,2 and SAV1 was lost in liver cancer. Based on systematic analysis, we identified KLF5 as YAP1 binding partner in silico. To investigate KLF5 in liver cancer, we performed the gene expression microarray after knocked down YAP1, TEAD1 and KLF5 in SK-Hep1 cell line.
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| Overall design |
To identify the role of YAP1, TEAD1 and KLF5 in hepatocellular carcinoma cell line, we performed microarray after knocking down YAP1, TEAD1 and KLF5 in hepatocellular carcinoma cell line (3 siLuc, 3 siYAP1, 3 siTEAD1, 3 siKLF5)
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| Contributor(s) |
Park Y, Kim SB, Lee J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 04, 2011 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Yun-Yong Park |
| E-mail(s) |
yypark@mdanderson.org
|
| Phone |
7137458525
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| Fax |
7135634235
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| URL |
http://www.mdanderson.org
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| Organization name |
UT, MD Anderson Cancer Center
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| Department |
Systems Biology
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| Street address |
7435 Fannin St.
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77054 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA147181 |
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