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| Status |
Public on Oct 16, 2011 |
| Title |
Effect of iron chelators on global gene expression pattern in SW480 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression analysis of SW480 cells treated with inhibitor compounds for 6 hours. Results provide insights into the role of iron in Wnt signalling and demonstrate that iron depletion is the primary mode of actions of these compounds on Wnt pathway.
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| Overall design |
SW480 cells were incubated with 10 mM of compounds (OICR623), control (DMSO) and two known iron chelators (DFO and Deferasirox) for 6 hours. RNA was extracted and cDNA samples isolated from 2-4 independent experiments were hybridized to the Affymetrix GeneChip® Human Gene 1.0 ST array.
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| Contributor(s) |
Attisano L, Jeff W |
| Citation(s) |
22009536 |
| Submission date |
Sep 26, 2011 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Liliana Attisano |
| E-mail(s) |
liliana.attisano@utoronto.ca
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| Organization name |
University of Toronto
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| Department |
Biochemistry
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| Lab |
Attisano
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| Street address |
160 College Street
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| City |
Toronto |
| State/province |
Ontario |
| ZIP/Postal code |
M5S 3E1 |
| Country |
Canada |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (13)
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| GSM801405 |
treated (DFO), biological rep2 |
| GSM801406 |
treated (OICR623), biological rep1 |
| GSM801407 |
treated (Deferasirox), biological rep1 |
| GSM801408 |
control (DMSO), biological rep3 |
| GSM801409 |
treated (DFO), biological rep3 |
| GSM801410 |
treated (OICR623), biological rep2 |
| GSM801411 |
treated (Deferasirox), biological rep2 |
| GSM801412 |
control (DMSO), biological rep4 |
| GSM801413 |
treated (DFO), biological rep4 |
| GSM801414 |
treated (Deferasirox), biological rep3 |
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| Relations |
| BioProject |
PRJNA147969 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32369_RAW.tar |
55.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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