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| Status |
Public on Sep 18, 2011 |
| Title |
Expression data from peripheral blood - blood draws at Pre and Post time points of Methacholine (MCh) inhalation challenge |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Evaluate the effect of methacholine-induced bronchoconstriction on the peripheral whole-blood transcriptome, post-challenge compared to pre-challenge.
Blood was collected immediately prior to, and two hours after challenge.
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| Overall design |
28 total blood samples (14 Pre- and 14 Post-challenge) were analyzed. Robust regression in the Linear Models for MicroArrays (LIMMA) was used to compaire gene expression between Pre and Post time points. No pre-filtering of probe sets was performed prior to statistical analyses. In addtion, and FDR of 10% was used to deteremine signifance of genes.
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| Contributor(s) |
He J, Tebbutt S, Shannnon C, Singh A, Charlsten C |
| Citation |
Tebbutt, S.J., He, J.-Q., Singh, A., Shannon, C.P., Ruan, J., Carlsten, C. Transcriptional changes of blood eosinophils after methacholine inhalation challenge in asthmatics. Genomics Insights 5:1-12 (2012). http://www.la-press.com/Genomics-article-a3005
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| Submission date |
Sep 17, 2011 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Scott Tebbutt |
| E-mail(s) |
scott.tebbutt@hli.ubc.ca
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| Organization name |
University of British Columbia
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| Department |
Medicine
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| Lab |
James Hogg Research Centre
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| Street address |
Room 166, 1081 Burrard Street
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| City |
Vancouver |
| State/province |
BC |
| ZIP/Postal code |
V6Z 1Y6 |
| Country |
Canada |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (28)
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| GSM797812 |
Subject 503, biological rep2 |
| GSM797813 |
Subject 504, biological rep1 |
| GSM797814 |
Subject 504, biological rep2 |
| GSM797815 |
Subject 505, biological rep1 |
| GSM797816 |
Subject 505, biological rep2 |
| GSM797817 |
Subject 506, biological rep1 |
| GSM797818 |
Subject 506, biological rep2 |
| GSM797819 |
Subject 508, biological rep1 |
| GSM797820 |
Subject 508, biological rep2 |
| GSM797821 |
Subject 509, biological rep1 |
| GSM797822 |
Subject 509, biological rep2 |
| GSM797823 |
Subject 510, biological rep1 |
| GSM797824 |
Subject 510, biological rep2 |
| GSM797825 |
Subject 511, biological rep1 |
| GSM797826 |
Subject 511, biological rep2 |
| GSM797827 |
Subject 512, biological rep1 |
| GSM797828 |
Subject 512, biological rep2 |
| GSM797829 |
Subject 513, biological rep1 |
| GSM797830 |
Subject 513, biological rep2 |
| GSM797831 |
Subject 514, biological rep1 |
| GSM797832 |
Subject 514, biological rep2 |
| GSM797833 |
Subject 515, biological rep1 |
| GSM797834 |
Subject 515, biological rep2 |
| GSM797835 |
Subject 516, biological rep1 |
| GSM797836 |
Subject 516, biological rep2 |
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| Relations |
| BioProject |
PRJNA147381 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32198_RAW.tar |
107.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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