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| Status |
Public on Jan 04, 2012 |
| Title |
Targeted ErbB3 loss in mammary organoids harvested from ErbB3 DOX-KO mice +/- DOX treatment |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Mammary organoids harvested from ErbB3 DOX-KO mice, which utilize MMTV-Cre transgene expression in the LE to cause genomic recombination at floxed ErbB3 alleles in ErbB3FL/FL were cultured in the presence or absence of doxycycline to induce ErbB3 loss. The gene expression shift following DOX-induced ErbB3 loss in the 3D organoids was examined by microarray.
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| Overall design |
Gene expression patterns were interrogated in mammary organoids from ErbB3 inducible-knockout mice cultured in the presence of absence of doxycycline. Three biological replicates of the experiment were performed, resulting in a total of 6 samples (3 treatment, 3 control).
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| |
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| Contributor(s) |
Balko JM, Cook RS |
| Citation(s) |
22178756 |
| Submission date |
Sep 14, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Justin M Balko |
| Organization name |
Vanderbilt University
|
| Department |
Medicine
|
| Lab |
Arteaga
|
| Street address |
777 Preston Research Building
|
| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37232-6307 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
|
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| Relations |
| BioProject |
PRJNA147437 |
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