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| Status |
Public on Mar 01, 2012 |
| Title |
Role of SIRT1 in human hepatocellular carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To investigate the specific roles of SIRT1 in the development of hepatocellular carcinoma, we employed large-scale gene expression analysis to identify the molecular signature that may affect enabling characteristics of cancer cells. Differentially expressed genes were analyzed on the SNU-182 cells transfected with SIRT1 siRNA and recapitulated molecular signatures that related to hallmarks of cancer.
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| Overall design |
SIRT1 expression in hepatocellular carcinoma was analyzed by RT-PCR and western blot. RNA interference-mediated protein knockdown method was used to investigate oncogenic potential of SIRT1 in hepatocelluar carcinoma
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| Contributor(s) |
Bae H, Noh J, Kim J, Eun J, Jung K, Xie H, Kim M, Chang Y, Park W, Lee J, Nam S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 12, 2011 |
| Last update date |
Oct 18, 2022 |
| Contact name |
Jung Woo Eun |
| E-mail(s) |
jetaimebin@catholic.ac.kr
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| Organization name |
Ajou University of Korea
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| Street address |
Department of Gastroenterology
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| City |
Suwon, Korea |
| State/province |
Korea |
| ZIP/Postal code |
16499 |
| Country |
South Korea |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA147605 |
